Human Genetics

, Volume 99, Issue 2, pp 233–236

Human hepatocyte nuclear factor-4 (hHNF-4) gene maps to 20q12–q13.1 between PLCG1 and D20S17

Authors

  • Alexandros Argyrokastritis
    • Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology, P.O. Box 1527, GR-711 10 Heraklion, Greece Tel.: +30-81-212-469; Fax: 30-81-239-155 e-mail: moschon@victor.imbb.forth.gr
  • Smaragda Kamakari
    • Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology, P.O. Box 1527, GR-711 10 Heraklion, Greece Tel.: +30-81-212-469; Fax: 30-81-239-155 e-mail: moschon@victor.imbb.forth.gr
  • Manuela Kapsetaki
    • Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology, P.O. Box 1527, GR-711 10 Heraklion, Greece Tel.: +30-81-212-469; Fax: 30-81-239-155 e-mail: moschon@victor.imbb.forth.gr
  • Aristidis Kritis
    • Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology, P.O. Box 1527, GR-711 10 Heraklion, Greece Tel.: +30-81-212-469; Fax: 30-81-239-155 e-mail: moschon@victor.imbb.forth.gr
  • Iannis Talianidis
    • Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology, P.O. Box 1527, GR-711 10 Heraklion, Greece Tel.: +30-81-212-469; Fax: 30-81-239-155 e-mail: moschon@victor.imbb.forth.gr
  • N. K. Moschonas
    • Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology, P.O. Box 1527, GR-711 10 Heraklion, Greece Tel.: +30-81-212-469; Fax: 30-81-239-155 e-mail: moschon@victor.imbb.forth.gr
Original investigation

DOI: 10.1007/s004390050345

Cite this article as:
Argyrokastritis, A., Kamakari, S., Kapsetaki, M. et al. Hum Genet (1997) 99: 233. doi:10.1007/s004390050345

Abstract

Human hepatocyte nuclear factor 4 (hHNF-4) is a member of the nuclear hormone receptor superfamily and an important transcription factor and developmental regulator of liver-specific genes. Distinct hHNF-4 cDNAs corresponding to various HNF-4 isoforms have been recently characterised. Three cDNAs, hHNF-4A, B and C, are considered splice variants of a single hHNF-4 gene. We have mapped hHNF-4 to 20q12–q13.1 between PLCG1 and D20S17 by genetic linkage analysis, taking advantage of an adjacent PstI restriction fragment length polymorphism, (RFLP), and by fluorescence in situ hybridisation. hHFN-4 maps to chromosome 20 in a region syntenic with mouse chromosome 2 where the hnf-4 homologue has been assigned.

Copyright information

© Springer-Verlag Berlin Heidelberg 1997