Human Genetics

, Volume 99, Issue 1, pp 103–105

The high mobility group I-C gene (HMGI-C): polymorphism and genetic localization

  • C. S. Ishwad
  • M. D. Shriver
  • D. M. Lassige
  • R. E. Ferrell
Original investigation

DOI: 10.1007/s004390050320

Cite this article as:
Ishwad, C., Shriver, M., Lassige, D. et al. Hum Genet (1996) 99: 103. doi:10.1007/s004390050320

Abstract

We have identified a highly informative dinucleotide repeat in the 5′-flanking region of the human high mobility group I-C (HMGI-C) gene. This polymorphism consists of 18–37 copies of a (CT) repeat with an observed heterozygosity of 82–83% in African Americans and Caucasians. Linkage analysis in CEPH pedigrees localized the HMGI-C gene to chromosome region 12q13–15 with no recombination observed between HMCI-C and markers D12S102 and D12S8.

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • C. S. Ishwad
    • 1
  • M. D. Shriver
    • 1
  • D. M. Lassige
    • 1
  • R. E. Ferrell
    • 1
  1. 1.Department of Human Genetics, Graduate School of Public Health, 130 De Soto Street, University of Pittsburgh, PA 15261, USA Tel.: + 1-412-624-3018; Fax: +1-412-624-3020US