The high mobility group I-C gene (HMGI-C): polymorphism and genetic localization
- Cite this article as:
- Ishwad, C., Shriver, M., Lassige, D. et al. Hum Genet (1996) 99: 103. doi:10.1007/s004390050320
We have identified a highly informative dinucleotide repeat in the 5′-flanking region of the human high mobility group I-C (HMGI-C) gene. This polymorphism consists of 18–37 copies of a (CT) repeat with an observed heterozygosity of 82–83% in African Americans and Caucasians. Linkage analysis in CEPH pedigrees localized the HMGI-C gene to chromosome region 12q13–15 with no recombination observed between HMCI-C and markers D12S102 and D12S8.