, Volume 99, Issue 1, pp 103-105

The high mobility group I-C gene (HMGI-C): polymorphism and genetic localization

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Abstract

We have identified a highly informative dinucleotide repeat in the 5′-flanking region of the human high mobility group I-C (HMGI-C) gene. This polymorphism consists of 18–37 copies of a (CT) repeat with an observed heterozygosity of 82–83% in African Americans and Caucasians. Linkage analysis in CEPH pedigrees localized the HMGI-C gene to chromosome region 12q13–15 with no recombination observed between HMCI-C and markers D12S102 and D12S8.
Received: 16 February 1996 / Revised: 30 April 1996, 29 July 1996