Human Genetics

, Volume 99, Issue 1, pp 52–55

Possible control of dopamine β-hydroxylase via a codominant mechanism associated with the polymorphic (GT)n repeat at its gene locus in healthy individuals

  • J. Wei
  • C. N. Ramchand
  • Gwynneth P. Hemmings
Original investigation

DOI: 10.1007/s004390050310

Cite this article as:
Wei, J., Ramchand, C. & Hemmings, G. Hum Genet (1996) 99: 52. doi:10.1007/s004390050310

Abstract

Six allelic fragments were typed by a PCR-based process with a pair of primers specific for a sequence containing the polymorphic (GT)n repeat at the human dopamine β-hydroxylase (DBH) locus in 125 unrelated healthy individuals. Their frequencies among these individuals were 0.012 (A1), 0.08 (A2), 0.344 (A3), 0.548 (A4), 0.004 (A5) and 0.012 (A6); the two major alleles, A3 and A4, made up nearly 90% of the alleles. These individuals were divided into four groups according to the genotype they possessed, i.e. A3/A3, A4/A4, A3/A4 and others (mixed group). Kruskal-Wallis analysis revealed a significant difference in serum DBH activity among these four genetic groups (H = 32.7, P < 0.0001). The homozygotic genotypes, A3/A3 and A4/A4, were associated with low and high DBH activity, respectively, and the heterozygotic genotype, A3/A4, seemed to play a role in keeping the DBH activity at a moderate level. The present work suggests that the human DBH is likely to be controlled via a codominant mechanism associated with the dinucleotide repeat polymorphism at its gene locus.

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • J. Wei
    • 1
  • C. N. Ramchand
    • 1
  • Gwynneth P. Hemmings
    • 1
  1. 1.Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, Bryn Hyfryd, The Crescent, Bangor, Gwynedd LL 57 2AG, UK Tel. and Fax: +44 1248 354048; e-mail: jwei@hgmp.mrc.ac.ukGB