Original investigation

Human Genetics

, Volume 99, Issue 1, pp 38-41

First online:

Allelic variants of human calcitonin receptor in the Japanese population

  • M. NakamuraAffiliated withSecond Department of Pathology, Wakayama Medical College, 27-Kyubancho Wakayama City, Wakayama, 640 Japan Tel.: +81 734-26-8315; Fax: +81 734-33-2053
  • , Zhi-qiang ZhangAffiliated withSecond Department of Pathology, Wakayama Medical College, 27-Kyubancho Wakayama City, Wakayama, 640 Japan Tel.: +81 734-26-8315; Fax: +81 734-33-2053
  • , Liang ShanAffiliated withSecond Department of Pathology, Wakayama Medical College, 27-Kyubancho Wakayama City, Wakayama, 640 Japan Tel.: +81 734-26-8315; Fax: +81 734-33-2053
  • , Tomoyuki HisaAffiliated withSecond Department of Pathology, Wakayama Medical College, 27-Kyubancho Wakayama City, Wakayama, 640 Japan Tel.: +81 734-26-8315; Fax: +81 734-33-2053
  • , Mitsuyo SasakiAffiliated withDepartment of Pediatrics, Wakayama Medical College Kihoku Hospital, Wakayama, 649-71 Japan
  • , Ryuichi TsukinoAffiliated withDepartment of Pediatrics, Arita City Hospital, Wakayama, 649-03 Japan
  • , Toyoharu YokoiAffiliated withSecond Department of Pathology, Wakayama Medical College, 27-Kyubancho Wakayama City, Wakayama, 640 Japan Tel.: +81 734-26-8315; Fax: +81 734-33-2053
  • , Akio KanameAffiliated withKaname Clinic, Wakayama, 647 Japan
  • , Kennichi KakudoAffiliated withSecond Department of Pathology, Wakayama Medical College, 27-Kyubancho Wakayama City, Wakayama, 640 Japan Tel.: +81 734-26-8315; Fax: +81 734-33-2053

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Abstract

Evidence from cDNA cloning has shown that calcitonin receptors (CTRs) have seven potential transmembrane domains. In this study, structural analysis of CTRs from ten cultured human tumor cell lines and 117 human blood samples demonstrated allelic variants at the 1377th nucleotide in intracellular domain 4, expressing either proline or leucine as the 463rd amino acid. It was found that the variant with proline at this site was the more prevalent type of CTR among the Japanese population.