, Volume 107, Issue 6, pp 630-641
First online:
High-resolution Y chromosome haplotypes of Israeli and Palestinian Arabs reveal geographic substructure and substantial overlap with haplotypes of Jews
- Almut NebelAffiliated withDepartment of Hematology, Hebrew University, Hadassah Medical School and Hadassah University Hospital
- , Dvora FilonAffiliated withDepartment of Hematology, Hebrew University, Hadassah Medical School and Hadassah University Hospital
- , Deborah A. WeissAffiliated withDepartment of Anthropology, University of California
- , Michael WealeAffiliated withDepartment of Biology, University College London
- , Marina FaermanAffiliated withLaboratory of Biological Anthropology and Ancient DNA, Hebrew University, Hadassah School of Dental Medicine
- , Ariella OppenheimAffiliated withDepartment of Hematology, Hebrew University, Hadassah Medical School and Hadassah University Hospital Email author
- , Mark G. ThomasAffiliated withDepartment of Biology, University College London
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High-resolution Y chromosome haplotype analysis was performed in 143 paternally unrelated Israeli and Palestinian Moslem Arabs (I&P Arabs) by screening for 11 binary polymorphisms and six microsatellite loci. Two frequent haplotypes were found among the 83 detected: the modal haplotype of the I&P Arabs (∼14%) was spread throughout the region, while its one-step microsatellite neighbor, the modal haplotype of the Galilee sample (∼8%), was mainly restricted to the north. Geographic substructuring within the Arabs was observed in the highlands of Samaria and Judea. Y chromosome variation in the I&P Arabs was compared to that of Ashkenazi and Sephardic Jews, and to that of North Welsh individuals. At the haplogroup level, defined by the binary polymorphisms only, the Y chromosome distribution in Arabs and Jews was similar but not identical. At the haplotype level, determined by both binary and microsatellite markers, a more detailed pattern was observed. Single-step microsatellite networks of Arab and Jewish haplotypes revealed a common pool for a large portion of Y chromosomes, suggesting a relatively recent common ancestry. The two modal haplotypes in the I&P Arabs were closely related to the most frequent haplotype of Jews (the Cohen modal haplotype). However, the I&P Arab clade that includes the two Arab modal haplotypes (and makes up 32% of Arab chromosomes) is found at only very low frequency among Jews, reflecting divergence and/or admixture from other populations.
- Title
- High-resolution Y chromosome haplotypes of Israeli and Palestinian Arabs reveal geographic substructure and substantial overlap with haplotypes of Jews
- Journal
-
Human Genetics
Volume 107, Issue 6 , pp 630-641
- Cover Date
- 2000-12
- DOI
- 10.1007/s004390000426
- Print ISSN
- 0340-6717
- Online ISSN
- 1432-1203
- Publisher
- Springer-Verlag
- Additional Links
- Topics
- Industry Sectors
- Authors
-
- Almut Nebel (1)
- Dvora Filon (1)
- Deborah A. Weiss (2)
- Michael Weale (3)
- Marina Faerman (4)
-
Ariella Oppenheim
(1)
- Mark G. Thomas (3)
- Author Affiliations
-
- 1. Department of Hematology, Hebrew University, Hadassah Medical School and Hadassah University Hospital, 91120, Jerusalem, Israel
- 2. Department of Anthropology, University of California, Davis, USA
- 3. Department of Biology, University College London, London, UK
- 4. Laboratory of Biological Anthropology and Ancient DNA, Hebrew University, Hadassah School of Dental Medicine, Jerusalem, Israel