Review Paper

Human Genetics

, Volume 131, Issue 1, pp 33-39

Common variants for atrial fibrillation: results from genome-wide association studies

  • Xinyuan LiuAffiliated withDepartment of Pediatrics, Tongji Hospital, Tongji University School of MedicineKey Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine
  • , Fei WangAffiliated withDepartment of Gastroenterology, Tongji Hospital, Tongji University School of Medicine
  • , Ashley C. KnightAffiliated withCardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School
  • , Jiangmin ZhaoAffiliated withKey Laboratory of Arrhythmias, Ministry of Education, Tongji University School of MedicineDepartment of Radiology, East Hospital, Tongji University School of Medicine Email author 
  • , Junjie XiaoAffiliated withKey Laboratory of Arrhythmias, Ministry of Education, Tongji University School of MedicineCardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School Email author 

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Abstract

Atrial fibrillation (AF) affects more than 5 million people worldwide; however, none of the anti-arrhythmic drugs available now are entirely optimal in terms of efficacy and safety. A better understanding of the molecular mechanism of AF will facilitate the process of finding new strategies to prevent AF. As the non-familial AF is the major form of AF, identifying common variants for AF in these populations by genome-wide association studies will definitely accelerate this process. This review summarizes the recently identified common AF variants on 4q25, 16q22, and 1q21 and discusses their implications for the clinic.