Common variants for atrial fibrillation: results from genome-wide association studies
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- Liu, X., Wang, F., Knight, A.C. et al. Hum Genet (2012) 131: 33. doi:10.1007/s00439-011-1052-3
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Atrial fibrillation (AF) affects more than 5 million people worldwide; however, none of the anti-arrhythmic drugs available now are entirely optimal in terms of efficacy and safety. A better understanding of the molecular mechanism of AF will facilitate the process of finding new strategies to prevent AF. As the non-familial AF is the major form of AF, identifying common variants for AF in these populations by genome-wide association studies will definitely accelerate this process. This review summarizes the recently identified common AF variants on 4q25, 16q22, and 1q21 and discusses their implications for the clinic.