Human Genetics

, Volume 131, Issue 1, pp 33–39

Common variants for atrial fibrillation: results from genome-wide association studies

Review Paper

DOI: 10.1007/s00439-011-1052-3

Cite this article as:
Liu, X., Wang, F., Knight, A.C. et al. Hum Genet (2012) 131: 33. doi:10.1007/s00439-011-1052-3

Abstract

Atrial fibrillation (AF) affects more than 5 million people worldwide; however, none of the anti-arrhythmic drugs available now are entirely optimal in terms of efficacy and safety. A better understanding of the molecular mechanism of AF will facilitate the process of finding new strategies to prevent AF. As the non-familial AF is the major form of AF, identifying common variants for AF in these populations by genome-wide association studies will definitely accelerate this process. This review summarizes the recently identified common AF variants on 4q25, 16q22, and 1q21 and discusses their implications for the clinic.

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Department of PediatricsTongji Hospital, Tongji University School of MedicineShanghaiChina
  2. 2.Key Laboratory of Arrhythmias, Ministry of EducationTongji University School of MedicineShanghaiChina
  3. 3.Department of GastroenterologyTongji Hospital, Tongji University School of MedicineShanghaiChina
  4. 4.Cardiovascular InstituteBeth Israel Deaconess Medical Center, Harvard Medical SchoolBostonUSA
  5. 5.Department of RadiologyEast Hospital, Tongji University School of MedicineShanghaiChina