Identification of an autosomal recessive stuttering locus on chromosome 3q13.2–3q13.33
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- Raza, M.H., Riazuddin, S. & Drayna, D. Hum Genet (2010) 128: 461. doi:10.1007/s00439-010-0871-y
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Stuttering is a common speech disorder with substantial genetic contributions. To better understand the genetic factors involved in stuttering, we performed a genome-wide linkage study in a newly-ascertained consanguineous stuttering family from Pakistan. A linkage scan in this family using parametric linkage analysis revealed significant linkage only on chromosome 3q13.2–3q13.33, with a maximum two-point LOD score of 4.23 under an autosomal recessive model of inheritance.