Human Genetics

, Volume 128, Issue 4, pp 461–463

Identification of an autosomal recessive stuttering locus on chromosome 3q13.2–3q13.33

  • Muhammad Hashim Raza
  • Sheikh Riazuddin
  • Dennis Drayna
Short Report

DOI: 10.1007/s00439-010-0871-y

Cite this article as:
Raza, M.H., Riazuddin, S. & Drayna, D. Hum Genet (2010) 128: 461. doi:10.1007/s00439-010-0871-y

Abstract

Stuttering is a common speech disorder with substantial genetic contributions. To better understand the genetic factors involved in stuttering, we performed a genome-wide linkage study in a newly-ascertained consanguineous stuttering family from Pakistan. A linkage scan in this family using parametric linkage analysis revealed significant linkage only on chromosome 3q13.2–3q13.33, with a maximum two-point LOD score of 4.23 under an autosomal recessive model of inheritance.

Copyright information

© US Government 2010

Authors and Affiliations

  • Muhammad Hashim Raza
    • 1
    • 2
  • Sheikh Riazuddin
    • 2
    • 3
  • Dennis Drayna
    • 1
    • 4
  1. 1.National Institute on Deafness and Other Communication Disorders, National Institutes of HealthBethesdaUSA
  2. 2.Center of Excellence in Molecular BiologyPunjab UniversityLahorePakistan
  3. 3.Allama Iqbal Medical CollegeLahorePakistan
  4. 4.NIDCD/NIHRockvilleUSA