Human Genetics

, Volume 128, Issue 4, pp 461–463

Identification of an autosomal recessive stuttering locus on chromosome 3q13.2–3q13.33

Authors

  • Muhammad Hashim Raza
    • National Institute on Deafness and Other Communication Disorders, National Institutes of Health
    • Center of Excellence in Molecular BiologyPunjab University
  • Sheikh Riazuddin
    • Center of Excellence in Molecular BiologyPunjab University
    • Allama Iqbal Medical College
    • National Institute on Deafness and Other Communication Disorders, National Institutes of Health
    • NIDCD/NIH
Short Report

DOI: 10.1007/s00439-010-0871-y

Cite this article as:
Raza, M.H., Riazuddin, S. & Drayna, D. Hum Genet (2010) 128: 461. doi:10.1007/s00439-010-0871-y

Abstract

Stuttering is a common speech disorder with substantial genetic contributions. To better understand the genetic factors involved in stuttering, we performed a genome-wide linkage study in a newly-ascertained consanguineous stuttering family from Pakistan. A linkage scan in this family using parametric linkage analysis revealed significant linkage only on chromosome 3q13.2–3q13.33, with a maximum two-point LOD score of 4.23 under an autosomal recessive model of inheritance.

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© US Government 2010