Human Genetics

, Volume 128, Issue 2, pp 131–135

Association between genome-wide association studies reported SNPs and pediatric-onset Crohn’s disease in Canadian children

Authors

    • Department of PediatricsUniversity of Montreal
    • Research CentreSainte-Justine Hospital
  • David R. Mack
    • Division of Gastroenterology, Hepatology and NutritionChildren’s Hospital of Eastern Ontario
  • Kenneth Morgan
    • Department of Human GeneticsMcGill University and the Research Institute of the McGill University Health Center
  • David Israel
    • Department of Gastroenterology, Hepatology and NutritionBritish Columbia’s Children’s Hospital
  • Colette Deslandres
    • Department of PediatricsUniversity of Montreal
    • Research CentreSainte-Justine Hospital
  • Ernest G. Seidman
    • Faculty of Medicine, Division of GastroenterologyMcGill University and the Research Institute of the McGill University Health Center
  • Phlippe Lambrette
    • Research CentreSainte-Justine Hospital
  • Irina Costea
    • Research CentreSainte-Justine Hospital
  • Alfreda Krupoves
    • Research CentreSainte-Justine Hospital
    • Department of Preventive and Social MedicineUniversity of Montreal
  • Houda Fegury
    • Research CentreSainte-Justine Hospital
  • Jinsong Dong
    • Research CentreSainte-Justine Hospital
  • Zia Xhu
    • Research CentreSainte-Justine Hospital
  • Guy Grimard
    • Research CentreSainte-Justine Hospital
    • Division of Orthopedics, Department of PediatricsUniversity of Montreal
  • Emile Levy
    • Research CentreSainte-Justine Hospital
    • Department of NutritionUniversity of Montreal
Original Investigation

DOI: 10.1007/s00439-010-0835-2

Cite this article as:
Amre, D.K., Mack, D.R., Morgan, K. et al. Hum Genet (2010) 128: 131. doi:10.1007/s00439-010-0835-2

Abstract

A recent pediatric-focused genome-wide association study has implicated three novel susceptibility loci for Crohn’ disease (CD).We aimed to investigate whether the three recently reported and other previously reported genes/loci were also associated with CD in Canadian children. A case–control design was implemented at three pediatric gastroenterology clinics in Canada. Children <19 years of age with a confirmed diagnosis of CD were recruited along with controls. Single nucleotide polymorphisms (SNPs) in 19 reported genes/loci were genotyped. Associations between individual SNPs and CD were examined. A total of 563 cases and 553 controls were studied. The mean (±SD) age of the cases was 12.3 (±3.2) years. Most cases were male (56.0%), had ileo-colonic disease (L3 ± L4, 48.8%) and inflammatory behavior (B1 ± p, 87.9%) at diagnosis. Allelic association analysis (two-tailed) showed that 8 of the 19 targeted SNPs were significantly associated with overall susceptibility for CD. Associations with one additional SNP was borderline non-significant. Significantly associated SNPs included SNPs rs1250550 (p = 0.026) and rs8049439 (p = 0.04), recently reported to be specifically associated with pediatric-onset CD.Based on the results, we confirmed associations between two of the three novel pediatric-CD loci and other regions reported for associations with either pediatric and/or adult-onset CD.

Copyright information

© Springer-Verlag 2010