Human Genetics

, Volume 128, Issue 1, pp 113–117

High-density SNP genotyping detects homogeneity of Spanish and French Basques, and confirms their genomic distinctiveness from other European populations

Authors

    • Genome Analysis Platform, Functional Genomics UnitCIC bioGUNE
  • Jon Álvarez-Busto
    • Genome Analysis Platform, Functional Genomics UnitCIC bioGUNE
  • Liher Imaz
    • Genome Analysis Platform, Functional Genomics UnitCIC bioGUNE
  • María Regueiro
    • Genome Analysis Platform, Functional Genomics UnitCIC bioGUNE
    • Department of Molecular and Human Genetics, College of MedicineFlorida International University
  • María Nerea Azcárate
    • Basque Foundation for Health Innovation and Research
    • Centro Vasco de Transfusión y Tejidos Humanos
  • Roberto Bilbao
    • Basque Foundation for Health Innovation and Research
  • Mikel Iriondo
    • Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and TechnologyUniversity of the Basque Country
  • Ana Gil
    • Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and TechnologyUniversity of the Basque Country
  • Andone Estonba
    • Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and TechnologyUniversity of the Basque Country
    • Genome Analysis Platform, Functional Genomics UnitCIC bioGUNE
Short Report

DOI: 10.1007/s00439-010-0833-4

Cite this article as:
Rodríguez-Ezpeleta, N., Álvarez-Busto, J., Imaz, L. et al. Hum Genet (2010) 128: 113. doi:10.1007/s00439-010-0833-4

Abstract

A recent study reported that Basques do not constitute a genetically distinct population, and that Basques from Spanish and French provinces do not show significant genetic similarity. These conclusions disagree with numerous previous studies, and are not consistent with the historical and linguistic evidence that supports the distinctiveness of Basques. In order to further investigate this controversy, we have genotyped 83 Spanish Basque individuals and used these data to infer population structure based on more than 60,000 single nucleotide polymorphisms of several European populations. Here, we present the first high-throughput analysis including Basques from Spanish and French provinces, and show that all Basques constitute a homogeneous group that can be clearly differentiated from other European populations.

Supplementary material

439_2010_833_MOESM1_ESM.doc (350 kb)
Supplementary material 1 (DOC 350 kb)

Copyright information

© Springer-Verlag 2010