Human Genetics

, Volume 127, Issue 3, pp 287–294

The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders

Authors

    • Asian Studies Network (ASNET), Division for International RelationsThe University of Tokyo
  • Izumi Naka
    • Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human SciencesUniversity of Tsukuba
  • Taro Yamauchi
    • Graduate School of Health SciencesHokkaido University
  • Kazumi Natsuhara
    • School of NursingFukuoka Prefectural University
  • Ryosuke Kimura
    • Transdisciplinary Research Organization for Subtropical and Island Studies (TRO-SIS)University of the Ryukyus
  • Minato Nakazawa
    • Department of Public Health, Graduate School of Medical SciencesGunma University
  • Takafumi Ishida
    • Department of Biological Sciences, Graduate School of ScienceThe University of Tokyo
  • Tsukasa Inaoka
    • Department of Human Ecology, Faculty of AgricultureSaga University
  • Yasuhiro Matsumura
    • Faculty of Health CareKiryu University
  • Yuji Ataka
    • School of Policy StudiesKwansei Gakuin University
  • Nao Nishida
    • Department of Human Genetics, Graduate School of MedicineThe University of Tokyo
  • Naoyuki Tsuchiya
    • Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human SciencesUniversity of Tsukuba
  • Ryutaro Ohtsuka
    • Japan Wildlife Research Center
    • Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human SciencesUniversity of Tsukuba
Original Investigation

DOI: 10.1007/s00439-009-0768-9

Cite this article as:
Furusawa, T., Naka, I., Yamauchi, T. et al. Hum Genet (2010) 127: 287. doi:10.1007/s00439-009-0768-9

Abstract

Various Pacific Island populations have experienced a marked increase in the prevalence of obesity in past decades. This study examined the association of a promoter polymorphism of the leptin gene (LEP), G-2548A (rs7799039), and two non-synonymous single nucleotide polymorphisms of the leptin receptor gene (LEPR), K109R (rs1137100) and Q223R (rs1137101), with body weight, body mass index (BMI) and obesity (BMI ≥ 30) in Pacific Islanders. A total of 745 Austronesian (AN)-speaking participants were analyzed after adjusting for age, gender, and population differences. The results revealed that carriers of the 223Q alleles of LEPR had significantly higher body weight (P = 0.0009) and BMI (P = 0.0022) than non-carriers (i.e., 223R homozygotes); furthermore, the 223Q carriers also had a significantly higher risk of obesity in comparison to non-carriers (P = 0.0222). The other two polymorphisms, G-2548A and K109R, were associated with neither body weight, BMI, nor obesity. The 223Q allele was widely found among the AN-speaking study subjects, thus suggesting that the LEPR Q223R polymorphism is one of the factors contributing to the high prevalence of obesity in the Pacific Island populations.

Copyright information

© Springer-Verlag 2009