Original Investigation

Human Genetics

, Volume 125, Issue 5, pp 627-631

ATG16L1 T300A polymorphism and Crohn’s disease susceptibility: evidence from 13,022 cases and 17,532 controls

  • Hai-Feng ZhangAffiliated withDepartment of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital, Guangxi Medical University
  • , Li-Xin QiuAffiliated withDepartment of Medical Oncology, Cancer Hospital, Shanghai Medical College, Fudan University
  • , Yu ChenAffiliated withDepartment of Laboratory Medicine, Shanghai Changzheng Hospital, Second Military Medical University
  • , Wa-Li ZhuAffiliated withDepartment of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital, Guangxi Medical University
  • , Chen MaoAffiliated withDepartment of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University
  • , Li-Guang ZhuAffiliated withDepartment of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital, Guangxi Medical University Email author 
  • , Ming-Hua ZhengAffiliated withDepartment of Infection and Liver Diseases, The First Affiliated Hospital of Wenzhou Medical College
  • , Yan WangAffiliated withDepartment of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital, Guangxi Medical University
  • , Lei LeiAffiliated withDepartment of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital, Guangxi Medical University
    • , Jian ShiAffiliated withDepartment of Gastroenterology, Shanghai Changzheng Hospital, Second Military Medical University Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Many studies have reported the association between the autophagy-related 16-like 1 gene (ATG16L1) T300A polymorphism (rs2241880) and Crohn’s disease (CD) susceptibility, but the results were inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 24 studies including 13,022 cases and 17,532 controls were included in this meta-analysis. Logistic regression analysis indicated that the ATG16L1 T300A polymorphism was associated with CD risk in Caucasians (P < 0.01). The pooled estimations of OR1 (GG vs. AA) and OR2 (GA vs. AA) in Caucasian studies by Bayesian meta-analysis method was [1.87, 95% confidence interval (CI) 1.69–2.05] and (1.39, 95% CI 1.27–1.51), respectively. The mode of heritance of the G allele was most likely to be co-dominant in Caucasians. However, no significant association was found in Asians. This meta-analysis suggests that the G allele of ATG16L1 T300A is a low-penetrant gene for developing CD in Caucasians.