Human Genetics

, Volume 125, Issue 1, pp 105–109

A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility

  • Mahamadou Diakite
  • Taane G. Clark
  • Sarah Auburn
  • Susana Campino
  • Andrew E. Fry
  • Angela Green
  • Andrew P. Morris
  • Anna Richardson
  • Muminatou Jallow
  • Fatou Sisay-Joof
  • Margaret Pinder
  • Dominic P. Kwiatkowski
  • Kirk A. Rockett
Short Report

DOI: 10.1007/s00439-008-0597-2

Cite this article as:
Diakite, M., Clark, T.G., Auburn, S. et al. Hum Genet (2009) 125: 105. doi:10.1007/s00439-008-0597-2

Abstract

The tumour necrosis factor (TNF) gene and other genes flanking it in the major histocompatibility complex (MHC) class III region are potentially important mediators of both immunity and pathogenesis of malaria. We investigated the association of severe malaria with 11 haplotype tagging-polymorphisms for 11 MHC class III candidate genes, including TNF, lymphotoxin alpha (LTA), allograft inflammatory factor 1 (AIF1), and HLA-B associated transcript 2 (BAT2). An analysis of 2,162 case-controls demonstrated the first evidence of association between a BAT2 polymorphism (rs1046089) and severe malaria.

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Mahamadou Diakite
    • 1
    • 2
  • Taane G. Clark
    • 1
    • 3
  • Sarah Auburn
    • 3
  • Susana Campino
    • 3
  • Andrew E. Fry
    • 1
  • Angela Green
    • 1
  • Andrew P. Morris
    • 1
  • Anna Richardson
    • 1
  • Muminatou Jallow
    • 4
  • Fatou Sisay-Joof
    • 4
  • Margaret Pinder
    • 4
  • Dominic P. Kwiatkowski
    • 1
    • 3
  • Kirk A. Rockett
    • 1
  1. 1.Wellcome Trust Centre for Human GeneticsUniversity of OxfordOxfordUK
  2. 2.Malaria Research and Training Centre, Faculty of Medicine, Pharmacy and OdontostomatologyUniversity of BamakoBamakoMali
  3. 3.Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusHinxtonUK
  4. 4.Medical Research Council LaboratoriesBanjulGambia