MLXIPL variant in individuals with low and high triglyceridemia in white population in Central Europe
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- Vrablik, M., Ceska, R., Adamkova, V. et al. Hum Genet (2008) 124: 553. doi:10.1007/s00439-008-0577-6
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We tested the hypothesis that the MLXIPL rs3812316 variant predicts plasma triglyceride (TG) levels. We compared three groups of adult individuals: 162 persons with TG > 10 mmol/L, 266 persons with TG < 0.65 mmol/L, and 2,043 population-based controls (range of TG concentrations 0.7–8.7 mmol/L). We found a small difference in the frequency of the Gln allele carriers between population controls (20.4%) and persons with low TG (26.3%, P = 0.033). We found no difference between individuals with high TG and population controls, and there was no association between the MLXIPL variant and plasma TG levels among the population controls.