Original Investigation

Human Genetics

, Volume 124, Issue 1, pp 95-99

Replication of association between ELAVL4 and Parkinson disease: the GenePD study

  • Anita L. DeStefanoAffiliated withDepartment of Biostatistics, Boston University School of Public HealthDepartment of Neurology, Boston University School of Medicine Email author 
  • , Jeanne LatourelleAffiliated withDepartment of Neurology, Boston University School of Medicine
  • , Mark F. LewAffiliated withDepartment of Neurology, University Southern California School of Medicine
  • , Oksana SuchowerskyAffiliated withDepartment of Clinical Neuroscience, University of Calgary
  • , Christine KleinAffiliated withDepartment of Neurology, University of Lübeck
  • , Lawrence I. GolbeAffiliated withDepartment of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School
  • , Margery H. MarkAffiliated withDepartment of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School
  • , John H. GrowdonAffiliated withDepartment of Neurology, Massachusetts General Hospital
  • , G. Fredrick WootenAffiliated withDepartment of Neurology, University of Virginia Health System
    • , Ray WattsAffiliated withDepartment of Neurology, University of Alabama at Birmingham
    • , Mark GuttmanAffiliated withDepartment of Biostatistics, Boston University School of Public HealthDepartment of Medicine, University of Toronto
    • , Brad A. RacetteAffiliated withDepartment of Biostatistics, Boston University School of Public HealthDepartment of Neurology, Washington University School of Medicine
    • , Joel S. PerlmutterAffiliated withDepartment of Biostatistics, Boston University School of Public HealthDepartment of Neurology, Washington University School of Medicine
    • , Lynn MarlorAffiliated withDepartment of Biostatistics, Boston University School of Public HealthBarrow Neurological Institute
    • , Holly A. ShillAffiliated withDepartment of Biostatistics, Boston University School of Public HealthSun Health Research Institute
    • , Carlos SingerAffiliated withDepartment of Biostatistics, Boston University School of Public HealthDepartment of Neurology, University of Miami
    • , Stefano GoldwurmAffiliated withDepartment of Biostatistics, Boston University School of Public HealthParkinson Institute, Istituti Clinici di Perfezionamento
    • , Gianni PezzoliAffiliated withDepartment of Biostatistics, Boston University School of Public HealthParkinson Institute, Istituti Clinici di Perfezionamento
    • , Marie H. Saint-HilaireAffiliated withDepartment of Neurology, Boston University School of Medicine
    • , Audrey E. HendricksAffiliated withDepartment of Biostatistics, Boston University School of Public Health
    • , Adam GowerAffiliated withDepartment of Biostatistics, Boston University School of Public HealthDepartment of Bioinformatics, Boston University
    • , Sally WilliamsonAffiliated withDepartment of Neurology, Boston University School of Medicine
    • , Michael W. NagleAffiliated withDepartment of Neurology, Boston University School of Medicine
    • , Jemma B. WilkAffiliated withDepartment of Neurology, Boston University School of Medicine
    • , Tiffany MassoodAffiliated withDepartment of Neurology, Boston University School of Medicine
    • , Karen W. HuskeyAffiliated withDepartment of Biostatistics, Boston University School of Public HealthDepartment of Neurology, Boston University School of Medicine
    • , Kenneth B. BakerAffiliated withDepartment of Biostatistics, Boston University School of Public HealthDepartments of Neurology and Neuroscience, Cleveland Clinic Foundation
    • , Ilia ItinAffiliated withDepartment of Biostatistics, Boston University School of Public HealthDepartments of Neurology and Neuroscience, Cleveland Clinic Foundation
    • , Irene LitvanAffiliated withDepartment of Biostatistics, Boston University School of Public HealthDepartment of Neurology, University of Louisville School of Medicine
    • , Garth NicholsonAffiliated withDepartment of Biostatistics, Boston University School of Public HealthNeurology Department, University of Sydney ANZAC Research Institute, Concord Hospital
    • , Alastair CorbettAffiliated withDepartment of Biostatistics, Boston University School of Public HealthNeurology Department, University of Sydney ANZAC Research Institute, Concord Hospital
    • , Martha NanceAffiliated withDepartment of Neurology, Boston University School of MedicineStruthers Parkinson’s Center
    • , Edward DrasbyAffiliated withDepartment of Neurology, Boston University School of MedicinePort City Neurology
    • , Stuart IsaacsonAffiliated withDepartment of Neurology, Boston University School of MedicineParkinson’s Disease and Movement Disorder Center of Boca Raton
    • , David J. BurnAffiliated withDepartment of Neurology, Boston University School of MedicineInstitute for Ageing and Health/Regional Neurosciences Centre, Newcastle University
    • , Patrick F. ChinneryAffiliated withDepartment of Neurology, Boston University School of MedicineInstitute for Ageing and Health/Regional Neurosciences Centre, Newcastle University
    • , Peter P. PramstallerAffiliated withDepartment of Neurology, Boston University School of MedicineDepartment of Neurology, General Regional Hospital Bolzano
    • , Jomana Al-hintiAffiliated withDepartment of Neurology, Boston University School of MedicineDepartment of Neurology, University of Arkansas for Medical Sciences
    • , Anette T. MollerAffiliated withDepartment of Neurology, Boston University School of MedicineDepartment of Neurology, Aarhus University Hospital
    • , Karen OstergaardAffiliated withDepartment of Neurology, Boston University School of MedicineDepartment of Neurology, Aarhus University Hospital
    • , Scott J. ShermanAffiliated withDepartment of Neurology, Boston University School of MedicineDepartment of Neurology, University of Arizona
    • , Richard RoxburghAffiliated withDepartment of Neurology, Boston University School of MedicineDepartment of Neurology, Auckland City Hospital
    • , Barry SnowAffiliated withDepartment of Neurology, Boston University School of MedicineDepartment of Neurology, Auckland City Hospital
    • , John T. SlevinAffiliated withDepartment of Neurology, Boston University School of MedicineDepartment of Neurology, University of Kentucky College of Medicine
    • , Franca CambiAffiliated withDepartment of Neurology, Boston University School of MedicineDepartment of Neurology, University of Kentucky College of Medicine
    • , James F. GusellaAffiliated withDepartment of Neurology, University Southern California School of MedicineMolecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School Boston
    • , Richard H. MyersAffiliated withDepartment of Neurology, Boston University School of Medicine

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations. In the current study we genotyped three single nucleotide polymorphisms in ELAVL4 in a Caucasian study sample consisting of 712 PD patients and 312 unrelated controls from the GenePD study. The minor allele of rs967582 was associated with increased risk of PD (odds ratio = 1.46, nominal P value = 0.011) in the GenePD population. The minor allele of rs967582 was also the risk allele for PD affection or earlier onset age in the previously studied populations. This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene.