Human Genetics

, 123:495

Substance dependence low-density whole genome association study in two distinct American populations

Authors

  • Yi Yu
    • Departments of Medicine (Genetics Program)Boston University Schools of Medicine and Public Health
  • Henry R. Kranzler
    • Department of PsychiatryUniversity of Connecticut School of Medicine
  • Carolien Panhuysen
    • Departments of Medicine (Genetics Program)Boston University Schools of Medicine and Public Health
    • Departments of BiostatisticsBoston University Schools of Medicine and Public Health
  • Roger D. Weiss
    • Department of Psychiatry, Harvard Medical SchoolAlcohol and Drug Abuse Treatment Program, McLean Hospital
  • James Poling
    • Department of Psychiatry, Division of Human GeneticsYale University School of Medicine; and VA CT Healthcare Center
  • Lindsay A. Farrer
    • Departments of Medicine (Genetics Program)Boston University Schools of Medicine and Public Health
    • Departments of BiostatisticsBoston University Schools of Medicine and Public Health
    • Departments of Neurology, Genetics and Genomics, EpidemiologyBoston University Schools of Medicine and Public Health
    • Department of Psychiatry, Division of Human GeneticsYale University School of Medicine; and VA CT Healthcare Center
    • Departments of Neurobiology and GeneticsYale University School of Medicine
Original Investigation

DOI: 10.1007/s00439-008-0501-0

Cite this article as:
Yu, Y., Kranzler, H.R., Panhuysen, C. et al. Hum Genet (2008) 123: 495. doi:10.1007/s00439-008-0501-0

Abstract

Cocaine and opioid dependence are common, complex disorders with high heritability that commonly co-occur with other substance dependence disorders. Improved insight into the genetic basis of substance dependence would help elucidate its etiology and could inform its prevention and treatment. To generate new hypotheses about the genetics of substance dependence, we genotyped 5633 tagging single nucleotide polymorphism (SNP) markers in 1699 subjects from 339 African American (AA) families and 334 European American (EA) families ascertained through a sib pair meeting DSM-IV criteria for either cocaine or opioid dependence. The associations between genetic markers and five substance dependence traits (cocaine dependence, opioid dependence, cocaine-induced paranoia, alcohol dependence, and nicotine dependence) were assessed by family based association tests (FBAT). Results were ranked according to several criteria including statistical significance, concordance of results across population samples, and potential biological relevance of the implicated gene. The top-ranked result was an association of SNP rs1133503 in the MANEA gene with cocaine-induced paranoia (CIP). Our study provides an initial substance dependence trait-specific blueprint of associated regions for future candidate gene studies.

Copyright information

© Springer-Verlag 2008