Human Genetics

, Volume 123, Issue 4, pp 419–427

Chromosomal regions 22q13 and 3p25 may harbor quantitative trait loci influencing both age at menarche and bone mineral density

  • Feng Pan
  • Peng Xiao
  • Yan Guo
  • Yong-Jun Liu
  • Hong-Yi Deng
  • Robert R. Recker
  • Hong-Wen Deng
Original Investigation

DOI: 10.1007/s00439-008-0490-z

Cite this article as:
Pan, F., Xiao, P., Guo, Y. et al. Hum Genet (2008) 123: 419. doi:10.1007/s00439-008-0490-z

Abstract

Late age at menarche (AAM), an important type of endocrinopathy in females, is associated with lower bone mineral density (BMD), a major risk factor for osteoporosis. The correlation is mainly mediated through common genetic factors, which are largely unknown. A bivariate genome-wide linkage scan was conducted on 2,522 females from 414 Caucasian pedigrees to identify quantitative trait loci influencing both AAM and BMD. The strongest linkage signal was detected on chromosome 22q13. Other regions such as the 3q13, 3p25, 7p15, and 15q13 were also suggested. The inferred promising candidate genes in the linkage regions may contribute to our understanding of pathogenesis of endocrinopathy and osteoporosis in females.

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Feng Pan
    • 1
    • 2
  • Peng Xiao
    • 2
  • Yan Guo
    • 1
  • Yong-Jun Liu
    • 3
    • 4
  • Hong-Yi Deng
    • 3
    • 4
  • Robert R. Recker
    • 2
  • Hong-Wen Deng
    • 1
    • 3
    • 4
    • 5
  1. 1.The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and TechnologyXi’an Jiaotong University Xi’anPeople’s Republic of China
  2. 2.Department of Biomedical Sciences and Osteoporosis Research Center, School of MedicineCreighton UniversityOmahaUSA
  3. 3.Department of Basic Medical Science, School of MedicineUniversity of Missouri-Kansas CityKansas CityUSA
  4. 4.Department of Orthopedic Surgery, School of MedicineUniversity of Missouri-Kansas CityKansas CityUSA
  5. 5.Laboratory of Molecular and Statistical GeneticsCollege of Life Sciences Hunan Normal UniversityChangshaPeople’s Republic of China