Human Genetics

, Volume 122, Issue 2, pp 129–139

Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation

  • Guillaume Lettre
  • Johannah L. Butler
  • Kristin G. Ardlie
  • Joel N. Hirschhorn
Original Investigation

DOI: 10.1007/s00439-007-0385-4

Cite this article as:
Lettre, G., Butler, J.L., Ardlie, K.G. et al. Hum Genet (2007) 122: 129. doi:10.1007/s00439-007-0385-4

Abstract

Stature (adult height) is one of the most heritable human traits, yet few genes, if any, have been convincingly associated with adult height variation in the general population. Here, we selected 150 tag SNPs from eight candidate genes in the growth hormone (GH)/insulin-like growth factor-1 (IGF1) axis (GHR, GHRH, GHRHR, IGF1, IGFALS, IGFBP3, JAK2, STAT5B), and genotyped them in ∼2,200 individuals ascertained for short or tall stature. Nominally significant tag SNPs were then tested in three additional replication cohorts, including a family-based panel to rule out spurious associations owing to population stratification. Across the four height cohorts (= 6,075 individuals), we did not observe any consistent associations between stature and common variants (≥5% minor allele frequency) in these eight genes, including a common deletion of the growth hormone receptor gene exon 3. Tests of epistatic interactions between these genes did not yield any results beyond those expected by chance. Although we have not tested all genes in the GH/IGF1 axis, our results indicate that common variation in these GH/IGF1 axis genes is not a major determinant of stature, and suggest that if common variation contributes to adult height variation in the general population, the variants are in other, possibly unanticipated genes.

Supplementary material

439_2007_385_MOESM1_ESM.eps (298 kb)
ESM1 (EPS 298 kb)
439_2007_385_MOESM2_ESM.doc (28 kb)
ESM2 (DOC 27.5 kb)
439_2007_385_MOESM3_ESM.doc (32 kb)
Supplementary Table 2. Summary of tagSNP strategy and coverage (DOC 31.5 kb)
439_2007_385_MOESM4_ESM.xls (54 kb)
ESM4 (XLS 54 kb)
439_2007_385_MOESM5_ESM.doc (32 kb)
Supplementary Table 4. Resequencing results (DOC 32 kb)
439_2007_385_MOESM6_ESM.xls (24 kb)
ESM6 (XLS 23.5 kb)

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Guillaume Lettre
    • 1
    • 2
  • Johannah L. Butler
    • 1
    • 2
  • Kristin G. Ardlie
    • 3
    • 4
  • Joel N. Hirschhorn
    • 1
    • 2
    • 5
  1. 1.Program in Medical and Population GeneticsBroad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge CenterCambridgeUSA
  2. 2.Divisions of Endocrinology and Genetics, Program in GenomicsChildren’s HospitalBostonUSA
  3. 3.Genomics Collaborative/Seracare LifeSciencesCambridgeUSA
  4. 4.Biological Samples PlatformBroad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge CenterCambridgeUSA
  5. 5.Department of GeneticsHarvard Medical SchoolBostonUSA