Human Genetics

, Volume 121, Issue 5, pp 635–637

The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer

Authors

  • George Zogopoulous
    • Sam Minuk Cancer Genetics and Biomarker LaboratoriesSamuel Lunenfeld Research Institute
    • Familial Gastrointestinal Cancer RegistryMount Sinai Hospital
  • Heidi Rothenmund
    • Sam Minuk Cancer Genetics and Biomarker LaboratoriesSamuel Lunenfeld Research Institute
    • Familial Gastrointestinal Cancer RegistryMount Sinai Hospital
  • Ayelet Eppel
    • Familial Gastrointestinal Cancer RegistryMount Sinai Hospital
  • Colleen Ash
    • Sam Minuk Cancer Genetics and Biomarker LaboratoriesSamuel Lunenfeld Research Institute
  • Mohammad Reza Akbari
    • Women’s College Research InstituteUniversity of Toronto
  • David Hedley
    • Department of Medical Oncology and Hematology and Division of Experimental Therapeutics, Ontario Cancer Institute/Princess Margaret HospitalUniversity of Toronto
  • Steven A. Narod
    • Women’s College Research InstituteUniversity of Toronto
    • Sam Minuk Cancer Genetics and Biomarker LaboratoriesSamuel Lunenfeld Research Institute
    • Familial Gastrointestinal Cancer RegistryMount Sinai Hospital
    • Mount Sinai Hospital
Short Report

DOI: 10.1007/s00439-007-0361-z

Cite this article as:
Zogopoulous, G., Rothenmund, H., Eppel, A. et al. Hum Genet (2007) 121: 635. doi:10.1007/s00439-007-0361-z

Abstract

The P239S palladin variant has recently been suggested to play a role in hereditary pancreatic cancer. We estimated the contribution of the P239S variant, and surrounding sequence, to familial and early-onset pancreatic cancer. The P239S germline variant was identified in one of 84 high-risk cases and one of 555 controls. The case reported an elderly relative with pancreas cancer. We conclude that this variant does not appear to account for a significant fraction of hereditary or early-onset pancreas cancer.

Supplementary material

Copyright information

© Springer-Verlag 2007