, Volume 121, Issue 5, pp 635-637

The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer

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Abstract

The P239S palladin variant has recently been suggested to play a role in hereditary pancreatic cancer. We estimated the contribution of the P239S variant, and surrounding sequence, to familial and early-onset pancreatic cancer. The P239S germline variant was identified in one of 84 high-risk cases and one of 555 controls. The case reported an elderly relative with pancreas cancer. We conclude that this variant does not appear to account for a significant fraction of hereditary or early-onset pancreas cancer.

An erratum to this article can be found at http://dx.doi.org/10.1007/s00439-007-0377-4