Human Genetics

, Volume 121, Issue 5, pp 635–637

The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer

  • George Zogopoulous
  • Heidi Rothenmund
  • Ayelet Eppel
  • Colleen Ash
  • Mohammad Reza Akbari
  • David Hedley
  • Steven A. Narod
  • Steven Gallinger
Short Report

DOI: 10.1007/s00439-007-0361-z

Cite this article as:
Zogopoulous, G., Rothenmund, H., Eppel, A. et al. Hum Genet (2007) 121: 635. doi:10.1007/s00439-007-0361-z

Abstract

The P239S palladin variant has recently been suggested to play a role in hereditary pancreatic cancer. We estimated the contribution of the P239S variant, and surrounding sequence, to familial and early-onset pancreatic cancer. The P239S germline variant was identified in one of 84 high-risk cases and one of 555 controls. The case reported an elderly relative with pancreas cancer. We conclude that this variant does not appear to account for a significant fraction of hereditary or early-onset pancreas cancer.

Supplementary material

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • George Zogopoulous
    • 1
    • 2
  • Heidi Rothenmund
    • 1
    • 2
  • Ayelet Eppel
    • 2
  • Colleen Ash
    • 1
  • Mohammad Reza Akbari
    • 3
  • David Hedley
    • 4
  • Steven A. Narod
    • 3
  • Steven Gallinger
    • 1
    • 2
    • 5
  1. 1.Sam Minuk Cancer Genetics and Biomarker LaboratoriesSamuel Lunenfeld Research InstituteTorontoCanada
  2. 2.Familial Gastrointestinal Cancer RegistryMount Sinai HospitalTorontoCanada
  3. 3.Women’s College Research InstituteUniversity of TorontoTorontoCanada
  4. 4.Department of Medical Oncology and Hematology and Division of Experimental Therapeutics, Ontario Cancer Institute/Princess Margaret HospitalUniversity of TorontoTorontoCanada
  5. 5.Mount Sinai HospitalTorontoCanada