Human Genetics

, Volume 117, Issue 1, pp 34–42

Genetic evidence in support of a shared Eurasian-North African dairying origin

Authors

    • Institute of Biological AnthropologyUniversity of Oxford
    • Department of Evolutionary GeneticsMax-Planck Institute for Evolutionary Anthropology
  • Nourdine Bouzekri
    • Institute of Biological AnthropologyUniversity of Oxford
  • Eden Haverfield
    • Institute of Biological AnthropologyUniversity of Oxford
    • Department of Human GeneticsUniversity of Chicago
  • Mohamed Cherkaoui
    • Laboratoire d’Ecologie Humaine, Faculté des Sciences-SemlaliaUniversité Cadi Ayyad
  • Jean-Michel Dugoujon
    • Centre d’Anthropologie CNRS,University of Toulouse
  • Ryk Ward
    • Institute of Biological AnthropologyUniversity of Oxford
Original Investigation

DOI: 10.1007/s00439-005-1266-3

Cite this article as:
Myles, S., Bouzekri, N., Haverfield, E. et al. Hum Genet (2005) 117: 34. doi:10.1007/s00439-005-1266-3

Abstract

The process by which pastoralism and agriculture spread from the Fertile Crescent over the past 10,000 years has been the subject of intense investigation by geneticists, linguists and archaeologists. However, no consensus has been reached as to whether this Neolithic transition is best characterized by a demic diffusion (with a significant genetic input from migrating farmers) or a cultural diffusion (without substantial migration of farmers). Milk consumption and thus lactose tolerance are assumed to have spread with pastoralism and we propose that by looking at the relevant mutations in and around the lactase gene in human populations, we can gain insight into the origin(s) and spread of dairying. We genotyped the putatively causal allele for lactose tolerance (−13910T) and constructed haplotypes from several polymorphisms in and around the lactase gene (LCT) in three North African Berber populations and compared our results with previously published data. We found that the frequency of the −13910T allele predicts the frequency of lactose tolerance in several Eurasian and North African Berber populations but not in most sub-Saharan African populations. Our analyses suggest that contemporary Berber populations possess the genetic signature of a past migration of pastoralists from the Middle East and that they share a dairying origin with Europeans and Asians, but not with sub-Saharan Africans.

Copyright information

© Springer-Verlag 2005