Human Genetics

, Volume 118, Issue 2, pp 295–300

IL-10 promoter single nucleotide polymorphisms are significantly associated with resistance to leprosy

  • Dheeraj Malhotra
  • Katayoon Darvishi
  • Soni Sood
  • Swarkar Sharma
  • Chander Grover
  • Vineet Relhan
  • B. S. N. Reddy
  • R. N. K. Bamezai
Short Report

DOI: 10.1007/s00439-005-0042-8

Cite this article as:
Malhotra, D., Darvishi, K., Sood, S. et al. Hum Genet (2005) 118: 295. doi:10.1007/s00439-005-0042-8

Abstract

The minor haplotype −3575A/-2849G/-2763C in IL-10 promoter has been defined as a marker of disease resistance to leprosy and its severity in Brazilian population. Our investigation of six single-nucleotide polymorphisms (SNPs) in IL-10 promoter in 282 Indian leprosy patients and 266 healthy controls by direct PCR sequencing, however, showed that the extended haplotype: −3575T/-2849G/-2763C/-1082A/-819C/-592C was associated with resistance to leprosy per se and to the development of severe form of leprosy, using either a binomial (controls vs cases, P=0.01, OR=0.58, CI=0.37–0.89) or ordinal (controls vs paucibacillary vs multibacillary, P=0.004) model. Whereas, IL-10 haplotype −3575T/-2849G/-2763C/-1082A/-819T/-592A was associated with the risk of development of severe form of leprosy (P=0.0002) in contrast to the minor risk haplotype −3575T/-2849A/-2763C in the Brazilian population. The role of IL-10 promoter SNPs in Brazilian and Indian population strongly suggests the involvement of IL-10 locus in the outcome of leprosy.

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Dheeraj Malhotra
    • 1
  • Katayoon Darvishi
    • 1
  • Soni Sood
    • 2
  • Swarkar Sharma
    • 1
  • Chander Grover
    • 2
  • Vineet Relhan
    • 2
  • B. S. N. Reddy
    • 2
  • R. N. K. Bamezai
    • 1
  1. 1.National Centre of Applied Human Genetics, School of Life SciencesJawaharlal Nehru UniversityNew DelhiIndia
  2. 2.Department of Dermatology and Sexually Transmitted Diseases, Maulana Azad Medical CollegeLok Nayak Jai Prakash HospitalNew DelhiIndia