Effect of IciA protein on the expression of the nrd gene encoding ribonucleoside diphosphate reductase in E. coli
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- Han, J., Kwon, H., Yim, JB. et al. Mol Gen Genet (1998) 259: 610. doi:10.1007/s004380050854
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The E. coli nrd operon contains the genes encoding the two subunits of ribonucleoside diphosphate reductase. We found that the IciA protein binds specifically to the AT-rich upstream region of nrd promoter. In vivo overexpression of IciA increases the expression of nrd gene by four- to five-fold, suggesting that IciA functions as a transcriptional activator for the nrd gene.