Molecular and General Genetics MGG

, Volume 259, Issue 6, pp 610–614

Effect of IciA protein on the expression of the nrd gene encoding ribonucleoside diphosphate reductase in E. coli

  • J. S. Han
  • H. S. Kwon
  • J.-B. Yim
  • D. S. Hwang
ORIGINAL PAPER

DOI: 10.1007/s004380050854

Cite this article as:
Han, J., Kwon, H., Yim, JB. et al. Mol Gen Genet (1998) 259: 610. doi:10.1007/s004380050854

Abstract

The E. coli nrd operon contains the genes encoding the two subunits of ribonucleoside diphosphate reductase. We found that the IciA protein binds specifically to the AT-rich upstream region of nrd promoter. In vivo overexpression of IciA increases the expression of nrd gene by four- to five-fold, suggesting that IciA functions as a transcriptional activator for the nrd gene.

Key wordsnrdRibonucleoside diphosphate reductaseIciADnaA

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • J. S. Han
    • 1
  • H. S. Kwon
    • 1
  • J.-B. Yim
    • 1
  • D. S. Hwang
    • 1
  1. 1.Institute for Molecular Biology and Genetics, Seoul National University, Seoul 151–742, Korea Fax: +82-2-874-1206 E-mail: dshwang@plaza.snu.ac.krKR
  2. 2.Department of Microbiology, Seoul National University Seoul 151-742, KoreaKR
  3. 3.Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul 151-742, KoreaKR