Molecular and General Genetics MGG

, Volume 259, Issue 4, pp 383–387

A screen for lethal mutations in the chromosomal region 59AB suggests that bellwether encodes the alpha subunit of the mitochondrial ATP synthase in Drosophila melanogaster

  • H. Jacobs
  • R. Stratmann
  • C. F. Lehner
ORIGINAL PAPER

DOI: 10.1007/s004380050826

Cite this article as:
Jacobs, H., Stratmann, R. & Lehner, C. Mol Gen Genet (1998) 259: 383. doi:10.1007/s004380050826

Abstract

We report the isolation and complementation mapping of lethal mutations within the 59AB region on the second chromosome of Drosophila melanogaster. The newly induced lethal mutations in this region define four different complementation groups. Using existing and newly induced deficiencies, these loci can be assigned to three different chromosomal intervals. Moreover, complementation analysis with chromosomes carrying various P element insertions, in combination with a molecular characterization of the corresponding insertion sites, suggests that the previously described male sterile mutation bellwether is an allele of an essential gene that encodes the alpha subunit of the mitochondrial ATP synthase.

Key wordsbellwether moa ATP synthase Cyclin B Cell cycle 

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • H. Jacobs
    • 1
  • R. Stratmann
    • 1
  • C. F. Lehner
    • 1
  1. 1.Department of Genetics University of Bayreuth, Universitätsstr. 30 D-95447 Bayreuth, Germany Fax: +49-921-55-2710; e-mail: chle@uni-bayreuth.deDE

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