Original Paper

Molecular Genetics and Genomics

, Volume 288, Issue 11, pp 549-557

First online:

Genomic comparison of Salmonella typhimurium DT104 with non-DT104 strains

  • Er-Ying ZhaoAffiliated withGenomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University
  • , Hong-Xia BaoAffiliated withGenomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical UniversityHMU-UCFM Centre for Infection and Genomics, Harbin Medical University
  • , Le TangAffiliated withGenomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical UniversityHMU-UCFM Centre for Infection and Genomics, Harbin Medical University
  • , Qing-Hua ZouAffiliated withDepartment of Microbiology, Peking University Health Science CenterGenomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University Email author 
  • , Wei-Qiao LiuAffiliated withDepartments of Microbiology and Infectious Diseases, University of CalgaryDepartment of Neurology, Vancouver General Hospital
  • , Da-Ling ZhuAffiliated withDepartment of Biopharmaceuticals, Faculty of Pharmacy, Harbin Medical University
  • , Jessica ChinAffiliated withDepartments of Microbiology and Infectious Diseases, University of Calgary
  • , Ying-Ying DongAffiliated withDepartments of Microbiology and Infectious Diseases, University of Calgary
  • , Yong-Guo LiAffiliated withGenetic Diagnosis Laboratory of First Hospital, Harbin Medical University
    • , Feng-Lin CaoAffiliated withGenetic Diagnosis Laboratory of First Hospital, Harbin Medical University
    • , Cornelis PoppeAffiliated withLaboratory for Foodborne Zoonoses, Public Health Agency of Canada
    • , Kenneth E. SandersonAffiliated withDepartments of Microbiology and Infectious Diseases, University of Calgary
    • , Randal N. JohnstonAffiliated withDepartments of Biochemistry and Molecular Biology, University of Calgary
    • , Daoguo ZhouAffiliated withDepartment of Biological Sciences, Purdue University
    • , Gui-Rong LiuAffiliated withGenomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University Email author 
    • , Shu-Lin LiuAffiliated withGenomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical UniversityDepartment of Microbiology, Peking University Health Science CenterDepartments of Microbiology and Infectious Diseases, University of CalgaryDepartment of Biopharmaceuticals, Faculty of Pharmacy, Harbin Medical UniversityHMU-UCFM Centre for Infection and Genomics, Harbin Medical UniversityGenetic Diagnosis Laboratory of First Hospital, Harbin Medical University Email author 

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Abstract

DT104 emerged as a new branch of Salmonella typhimurium with resistance to multiple antimicrobials. To reveal some general genomic features of DT104 for clues of evolutionary events possibly associated with the emergence of this relatively new type of this pathogen, we mapped 11 independent DT104 strains and compared them with non-DT104 S. typhimurium strains. We found that all 11 DT104 strains contained three insertions absent in non-DT104 strains, i.e., the previously reported ST104, ST104B and ST64B. However, SGI-1, a genomic island known to be responsible for DT104 multidrug resistance, was not present in all DT104 strains examined in this study: one DT104 strain did not contain SGI-1 but carried a 144 kb plasmid, suggesting possible evolutionary relationships between the two DNA elements in the development of antimicrobial resistance.

Keywords

Salmonella typhimurium DT104 Antimicrobial resistance SGI-1