Molecular Genetics and Genomics

, Volume 288, Issue 11, pp 549–557

Genomic comparison of Salmonella typhimurium DT104 with non-DT104 strains

Authors

  • Er-Ying Zhao
    • Genomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China)Harbin Medical University
  • Hong-Xia Bao
    • Genomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China)Harbin Medical University
    • HMU-UCFM Centre for Infection and GenomicsHarbin Medical University
  • Le Tang
    • Genomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China)Harbin Medical University
    • HMU-UCFM Centre for Infection and GenomicsHarbin Medical University
    • Department of MicrobiologyPeking University Health Science Center
    • Genomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China)Harbin Medical University
  • Wei-Qiao Liu
    • Departments of Microbiology and Infectious DiseasesUniversity of Calgary
    • Department of NeurologyVancouver General Hospital
  • Da-Ling Zhu
    • Department of Biopharmaceuticals, Faculty of PharmacyHarbin Medical University
  • Jessica Chin
    • Departments of Microbiology and Infectious DiseasesUniversity of Calgary
  • Ying-Ying Dong
    • Departments of Microbiology and Infectious DiseasesUniversity of Calgary
  • Yong-Guo Li
    • Genetic Diagnosis Laboratory of First HospitalHarbin Medical University
  • Feng-Lin Cao
    • Genetic Diagnosis Laboratory of First HospitalHarbin Medical University
  • Cornelis Poppe
    • Laboratory for Foodborne ZoonosesPublic Health Agency of Canada
  • Kenneth E. Sanderson
    • Departments of Microbiology and Infectious DiseasesUniversity of Calgary
  • Randal N. Johnston
    • Departments of Biochemistry and Molecular BiologyUniversity of Calgary
  • Daoguo Zhou
    • Department of Biological SciencesPurdue University
    • Genomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China)Harbin Medical University
    • Genomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China)Harbin Medical University
    • Department of MicrobiologyPeking University Health Science Center
    • Departments of Microbiology and Infectious DiseasesUniversity of Calgary
    • Department of Biopharmaceuticals, Faculty of PharmacyHarbin Medical University
    • HMU-UCFM Centre for Infection and GenomicsHarbin Medical University
    • Genetic Diagnosis Laboratory of First HospitalHarbin Medical University
Original Paper

DOI: 10.1007/s00438-013-0762-8

Cite this article as:
Zhao, E., Bao, H., Tang, L. et al. Mol Genet Genomics (2013) 288: 549. doi:10.1007/s00438-013-0762-8
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Abstract

DT104 emerged as a new branch of Salmonella typhimurium with resistance to multiple antimicrobials. To reveal some general genomic features of DT104 for clues of evolutionary events possibly associated with the emergence of this relatively new type of this pathogen, we mapped 11 independent DT104 strains and compared them with non-DT104 S. typhimurium strains. We found that all 11 DT104 strains contained three insertions absent in non-DT104 strains, i.e., the previously reported ST104, ST104B and ST64B. However, SGI-1, a genomic island known to be responsible for DT104 multidrug resistance, was not present in all DT104 strains examined in this study: one DT104 strain did not contain SGI-1 but carried a 144 kb plasmid, suggesting possible evolutionary relationships between the two DNA elements in the development of antimicrobial resistance.

Keywords

Salmonella typhimuriumDT104Antimicrobial resistanceSGI-1

Copyright information

© Springer-Verlag Berlin Heidelberg 2013