Parasitology Research

, Volume 88, Issue 2, pp 97–101

Ultrastructural alterations induced by nifurtimox and another nitro derivative on epimastigotes of Trypanosoma cruzi

  • S. Muelas-Serrano
  • J. Pérez-Serrano
  • A. Gómez-Barrio
  • V. Arán
  • F. Rodríguez-Caabeiro
Original Paper

DOI: 10.1007/s004360100497

Cite this article as:
Muelas-Serrano, S., Pérez-Serrano, J., Gómez-Barrio, A. et al. Parasitol Res (2002) 88: 97. doi:10.1007/s004360100497

Abstract.

We report the ultrastructural alterations induced on epimastigotes by nifurtimox and 5-nitro-2-thienyl-malononitrile (5NO2TM), a novel compound with anti-Trypanosoma cruzi activity. Parasites treated with concentrations of nifurtimox lower than usually employed for this kind of study showed vacuolisation, alterations of the mitochondria, the nucleus and the ribosomes. 5NO2TM caused the same kind of damage, but to a greater degree. This result correlates with the fact that cultures treated with this compound experienced a greater loss of viability.

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • S. Muelas-Serrano
    • 1
  • J. Pérez-Serrano
    • 3
  • A. Gómez-Barrio
    • 1
  • V. Arán
    • 2
  • F. Rodríguez-Caabeiro
    • 3
  1. 1.Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, SpainSpain
  2. 2.Instituto de Química Médica, Consejo Superior de Investigaciones Científicas, C/Juan de la Cierva 3, 28003 Madrid, SpainSpain
  3. 3.Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Alcalá, 28871 Alcalá de Henares, SpainSpain