Parasitology Research

, Volume 85, Issue 2, pp 135–141

Th1-type cytokines improve resistance to murine cysticercosis caused by Taenia crassiceps

  • L. I. Terrazas
  • M. Cruz
  • M. Rodríguez-Sosa
  • R. Bojalil
  • F. García-Tamayo
  • C. Larralde
ORIGINAL PAPER

DOI: 10.1007/s004360050522

Cite this article as:
Terrazas, L., Cruz, M., Rodríguez-Sosa, M. et al. Parasitol Res (1999) 85: 135. doi:10.1007/s004360050522

Abstract

Resistance and susceptibility to different parasitic diseases have been associated with the predominance of Th1- or Th2-type immune responses. In experimental murine cysticercosis a Th1 response seems to be involved in resistance, whereas Th2 activity is associated with heavy parasite intensities. To test this notion the roles of Th1- and Th2-type cytokines in infected mice were studied after treatment with anticytokine monoclonal antibodies or with recombinant murine cytokines during early stages of infection. Mice receiving anti-interleukin 10 (IL-10) carried lower parasite intensities than did control mice and developed a strong Th1-type response, whereas mice receiving anti-interferon gamma (IFN-γ) showed a dramatic increase in susceptibility. Treatment with recombinant cytokines confirmed these results; mice receiving IFN-γ and IL-2 showed low parasite numbers, whereas IL-10 induced a significant increase in parasite loads. Thus, the Th1-type immune response plays a fundamental role in protection against Taenia crassiceps cysticercosis, whereas Th2, at least through IL-10, favors parasite establishment.

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • L. I. Terrazas
    • 1
  • M. Cruz
    • 1
  • M. Rodríguez-Sosa
    • 2
  • R. Bojalil
    • 2
  • F. García-Tamayo
    • 1
  • C. Larralde
    • 3
  1. 1.Department of Biology, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, México D.F. 04510, México Tel.: (525) 622-30-98; Fax: (525) 616-20-10
  2. 2.Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Department of Health Attention, Universidad Autónoma Metropolitana-Xochimilco, México, D.F. 14080, MexicoMX
  3. 3.Department of Immunology, Instituto de Investigaciones Biomédicas, U.N.A.M. México, D.F 04510, MexicoMX

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