Parasitology Research

, Volume 83, Issue 1, pp 57–59

Schistosoma mansoni: unisexual infections sensitize mice for granuloma formation around intravenously injected eggs

  • A. W. Cheever
  • F. A. Lewis
  • T. A. Wynn
ORIGINAL PAPER

DOI: 10.1007/s004360050208

Cite this article as:
Cheever, A., Lewis, F. & Wynn, T. Parasitol Res (1996) 83: 57. doi:10.1007/s004360050208
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Abstract

 Mice carrying unisexual infection with male or female Schistosoma mansoni for 9 weeks developed accelerated and augmented reactions to S. mansoni eggs injected intravenously. The size of circumoval granulomas observed in the lungs of unisexually infected mice did not differ significantly from the reactions seen in bisexually infected mice. Tissue eosinophilia in the granulomas was also augmented similarly over that in naive mice by unisexual or bisexual infection. The cross-reactivity between worm and egg antigens is relevant to the development of acute toxemic schistosomiasis mansoni and, perhaps, to the consideration of antigens to be used for vaccination against S. mansoni infection.

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • A. W. Cheever
    • 1
  • F. A. Lewis
    • 2
  • T. A. Wynn
    • 1
  1. 1.Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, National Institutes of Health, Bethesda, Maryland, 20892-0425, USAUS
  2. 2.Biomedical Research Institute, Rockville, Maryland USAUS

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