Short Communication

Parasitology Research

, Volume 82, Issue 1, pp 90-91

First online:

Glycoprotein A is the immunodominant antigen of pneumocystis carinii in mice following immunization

  • Francis GigliottiAffiliated withUniversity of Rochester Medical Center
  • , Tera McCoolAffiliated withUniversity of Rochester

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A rapid and simple dual enzyme-linked immunosorbent assay was developed to quantitate the relative frequency of monoclonal antibodies produced against Pneumocystis carinii glycoprotein A (gpA) or other antigens of P. carinii after immunization with whole organisms. In BALB/cj mice, P. carinii gpA was clearly the immunodominant antigen, with a quarter of all hybridomas secreting antibody directed against this molecule.