Parasitology Research

, Volume 106, Issue 5, pp 1245–1248

Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae)

  • Simone S. Grecco
  • Juliana Q. Reimão
  • Andre G. Tempone
  • Patricia Sartorelli
  • Paulete Romoff
  • Marcelo J. P. Ferreira
  • Oriana A. Fávero
  • Joao H. G. Lago
Short Communication

DOI: 10.1007/s00436-010-1771-8

Cite this article as:
Grecco, S.S., Reimão, J.Q., Tempone, A.G. et al. Parasitol Res (2010) 106: 1245. doi:10.1007/s00436-010-1771-8

Abstract

In the course of selection of new bioactive compounds from Brazilian flora, the crude MeOH extract from the leaves of Baccharis retusa DC. (Asteraceae) showed potential against Leishmania sp. and Trypanosoma cruzi. Chromatographic fractionation of the dichloromethane phase from MeOH extract yielded great amounts of the bioactive derivative, which was characterized as 5,6,7-trihydroxy-4′-methoxyflavanone. The structure of this compound was established on the basis of spectroscopic data analysis, mainly nuclear magnetic resonance and mass spectrometry.

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Simone S. Grecco
    • 1
  • Juliana Q. Reimão
    • 2
  • Andre G. Tempone
    • 2
  • Patricia Sartorelli
    • 1
  • Paulete Romoff
    • 3
  • Marcelo J. P. Ferreira
    • 3
  • Oriana A. Fávero
    • 3
  • Joao H. G. Lago
    • 1
  1. 1.Departamento de Ciências Exatas e da TerraUniversidade Federal de São Paulo—Campus DiademaDiademaBrazil
  2. 2.Laboratório de Toxinologia Aplicada, Serviço de Parasitologia, Divisão de Biologia MédicaInstituto Adolfo LutzSão PauloBrazil
  3. 3.Centro de Ciências e Humanidades e Centro de Ciências Biológicas e da SaúdeUniversidade Presbiteriana MackenzieSão PauloBrazil