Parasitology Research

, 105:281

CD4+ T cell response in early erythrocytic stage malaria: Plasmodium berghei infection in BALB/c and C57BL/6 mice

  • Akiko Shibui
  • Nobumichi Hozumi
  • Chiharu Shiraishi
  • Yoshitaka Sato
  • Hajime Iida
  • Sumio Sugano
  • Junichi Watanabe
Short Communication

DOI: 10.1007/s00436-009-1435-8

Cite this article as:
Shibui, A., Hozumi, N., Shiraishi, C. et al. Parasitol Res (2009) 105: 281. doi:10.1007/s00436-009-1435-8

Abstract

Plasmodium berghei ANKA causes lethal malaria in mice. It is well established that C57BL/6 mice die early with fulminant symptoms including convulsion, whereas BALB/c mice survive this phase and die later of anemia and prostration. Early death in C57BL/6 mice has been considered to result from the adverse effects of inflammatory cytokines. To elucidate the CD4+ T cell responses in early death due to severe malaria, the kinetics of CD4+ T cells were compared by analyzing cell surface markers and the production of cytokines and transcription factors. The results revealed that cytokine production by CD4+ T cells was induced as early as 5 days after infection and the maintenance of higher levels of IL-4 and IL-10 may be associated with the protection of BALB/c mice from early death. These results suggest that parasite control in the early phase of infection may be important for the development of an effective vaccine.

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Akiko Shibui
    • 1
  • Nobumichi Hozumi
    • 1
  • Chiharu Shiraishi
    • 1
  • Yoshitaka Sato
    • 1
  • Hajime Iida
    • 1
  • Sumio Sugano
    • 2
  • Junichi Watanabe
    • 3
  1. 1.Research Institute for Biological SciencesTokyo University of ScienceNodaJapan
  2. 2.Department of Medical Genomics, Graduate School of Frontier SciencesThe University of TokyoKashiwaJapan
  3. 3.Department of Parasitology, Institute of Medical ScienceThe University of TokyoMinatokuJapan