Parasitology Research

, Volume 104, Issue 6, pp 1251–1260

Perspectives on the Trypanosoma cruzi–host cell receptor interactions

  • Fernando Villalta
  • Julio Scharfstein
  • Anthony W. Ashton
  • Kevin M. Tyler
  • Fangxia Guan
  • Shankar Mukherjee
  • Maria F. Lima
  • Sandra Alvarez
  • Louis M. Weiss
  • Huan Huang
  • Fabiana S. Machado
  • Herbert B. Tanowitz
Review

DOI: 10.1007/s00436-009-1383-3

Cite this article as:
Villalta, F., Scharfstein, J., Ashton, A.W. et al. Parasitol Res (2009) 104: 1251. doi:10.1007/s00436-009-1383-3

Abstract

Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions. Some of the key receptors considered are those for thromboxane, bradykinin, and for the nerve growth factor TrKA. Other important receptors such as galectin-3, thrombospondin, and laminin are also discussed. Investigation into the molecular biology and cell biology of host receptors for T. cruzi may provide novel therapeutic targets.

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Fernando Villalta
    • 1
  • Julio Scharfstein
    • 2
  • Anthony W. Ashton
    • 3
    • 7
  • Kevin M. Tyler
    • 4
  • Fangxia Guan
    • 5
  • Shankar Mukherjee
    • 3
  • Maria F. Lima
    • 1
  • Sandra Alvarez
    • 3
  • Louis M. Weiss
    • 3
  • Huan Huang
    • 3
  • Fabiana S. Machado
    • 6
  • Herbert B. Tanowitz
    • 3
  1. 1.Department of Microbial Pathogenesis and Immune ResponseMeharry Medical CollegeNashvilleUSA
  2. 2.Department Immunobiology, Instituto de Biofísica Carlos Chagas FilhoFederal University of Rio de JaneiroRio de JaneiroBrazil
  3. 3.Department of PathologyAlbert Einstein College of MedicineBronxUSA
  4. 4.BioMedical Research Center, School of Medicine, Health Policy and PracticeUniversity of East AngliaNorwichUK
  5. 5.Bioengineering Department of Zhengzhou UniversityZhengzhouPeople’s Republic of China
  6. 6.Department of Biochemistry and Immunology, Institute of Biological SciencesFederal University of Minas GeraisBelo HorizonteBrazil
  7. 7.Division of Perinatal Research, Kolling Institute of Medical ResearchUniversity of SydneySydneyAustralia