Abstract
A 6-year-old male golden retriever, with an 8-month history of seizures and a clinical diagnosis of lymphoma in the central nervous system, was (at the owner’s request) euthanized after signs of respiratory distress and shock developed. Upon postmortem examination, the diagnoses of meningoencephalitis and pneumonia were made. A histological examination of selected tissues from both the lung and central nervous system revealed a severe, acute, multifocal, amoebic, embolic pneumonia and a severe, chronic, multifocal, nonsuppurative, amoebic meningoencephalitis. Indirect immunofluorescence analysis confirmed the presence of trophozoite and cyst stages of Balamuthia mandrillaris. This is the first report of B. mandrillaris (which is a free-living amoeba) causing fatal, multifocal granulomatous amoebiasis in a dog in Australia.
References
Anderson MP, Oosterhuis JE, Kennedy S, Benirschke K (1986) Pneumonia and meningoencephalitis due to amoeba in a lowland gorilla. J Zoo Anim Med 17:87–91
Canfield PJ, Vogelnest L, Cunningham MI, Visvesvara GS (1997) Amoebic meningoencephalitis caused by Balamuthia mandrillaris in an orangutan. Aust Vet J 75:97–100
Foreman O, Sykes J, Ball L, Yang N, De Cock H (2004) Disseminated infection with Balamuthia mandrillaris in a dog. Vet Pathol 41:506–510
Fuentealba IC, Wikse SE, Read WK, Edwards JF, Visvesvara GS (1992) Amebic meningoencephalitis in a sheep. J Am Vet Med Assoc 200:363–365
Kiderlen AF, Laube U (2004) Balamuthia mandrillaris, an opportunistic agent of granulomatous amebic encephalitis, infects the brain via the olfactory nerve pathway. Parasitol Res 94:49–52
Kinde H, Visvesvara GS, Barr BC, Nordhausen RW, Chiu PH (1998) Amebic meningoencephalitis caused by Balamuthia mandrillaris (leptomyxid ameba) in a horse. J Vet Diagn Invest 10:378–381
Martinez AJ, Visvesvara GS (1997) Free-living, amphizoic and opportunistic amebas. Brain Pathol 7:583–598
Martinez AJ, Visvesvara GS (2001) Balamuthia mandrillaris infection. J Med Microbiol 50:205–207
Martinez AJ, Schuster FL, Visvesvara GS (2001) Balamuthia mandrillaris: its pathogenic potential. J Eukaryot Microbiol Suppl:6S–9S
Reed RP, Cooke-Yarborough CM, Jaquiery AL, Grimwood K, Kemp AS, Su JC, Forsyth JR (1997) Fatal granulomatous amoebic encephalitis caused by Balamuthia mandrillaris. Med J Aust 167:82–84
Rideout BA, Gardiner CH, Stalis IH, Zuba JR, Hadfield T, Visvesvara GS (1997) Fatal infections with Balamuthia mandrillaris (a free-living amoeba) in gorillas and other Old World primates. Vet Pathol 34:15–22
Schuster FL, Visvesvara GS (2004) Free-living amoebae as opportunistic and non-opportunistic pathogens of humans and animals. Int J Parasitol 34:1001–1027
Schuster FL, Dunnebacke TH, Booton GC, Yagi S, Kohlmeier CK, Glaser C, Vugia D, Bakardjiev A, Azimi P, Maddux-Gonzalez M, Martinez AJ, Visvesvara GS (2003) Environmental isolation of Balamuthia mandrillaris associated with a case of amebic encephalitis. J Clin Microbiol 41:3175–3180
Visvesvara GS, Martinez AJ, Schuster FL, Leitch GJ, Wallace SV, Sawyer TK, Anderson M (1990) Leptomyxid ameba, a new agent of amebic meningoencephalitis in humans and animals. J Clin Microbiol 28:2750–2756
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The authors thank Professor KVF Jubb for helpful comments and suggestions.
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Finnin, P.J., Visvesvara, G.S., Campbell, B.E. et al. Multifocal Balamuthia mandrillaris infection in a dog in Australia. Parasitol Res 100, 423–426 (2007). https://doi.org/10.1007/s00436-006-0302-0
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DOI: https://doi.org/10.1007/s00436-006-0302-0