Parasitology Research

, Volume 100, Issue 3, pp 641–644

Antiplasmodial activity of triterpenoid isolated from whole plants of Viola genus from South Korea

Short Communication

DOI: 10.1007/s00436-006-0279-8

Cite this article as:
Moon, H., Jung, J. & Lee, J. Parasitol Res (2007) 100: 641. doi:10.1007/s00436-006-0279-8

Abstract

Species of the Viola genus, used in traditional medicines for the treatment of parasites, were collected and petroleum ether extract was obtained by sonication. The antiplasmodial activity of petroleum ether extracts was evaluated in vitro against the chloroquine-resistant FcB1 strain of Plasmodium falciparum. Bioactivity-guided fractionation of the petroleum ether extracts of the whole plants of Viola verecunda has led to the isolation of epi-oleanolic acid, a triterpenoid, displaying high antiplasmodial activity (IC50 0.18 μg/ml). This is the first report of the isolation and antiplasmodial activity of epi-oleanolic acid from this species.

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.National Center for Natural Products Research, School of PharmacyThe University of MississippiOxfordUSA
  2. 2.Department of Medicinal Chemistry, School of PharmacyThe University of MississippiOxfordUSA
  3. 3.Korea Research Institute of Bioscience and BiotechnologyDaejeonSouth Korea