, Volume 93, Issue 4, pp 322-327
Date: 05 Jun 2004

No change in parasite genotype during single episodes of Plasmodium falciparum malaria in Gabonese children

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Abstract

Patients living in endemic areas can carry a mixture of Plasmodium falciparum genotypes. To investigate the genetic composition of parasite genotypes in malaria patients during the acute phase of the infection, we performed close follow-ups of 17 Gabonese pediatric patients aged 2–7 years. Capillary blood samples were taken on admission and every 4–6 h after the start of quinine therapy. Merozoite surface protein 2 (MSP2) genotypes were used to assess the parasites’ genetic characteristics in each sample. We found that each patient carried parasites with the same genotypic pattern throughout the infection.