Parasitology Research

, Volume 93, Issue 1, pp 8–16

The severity of mouse pathologies caused by the bird schistosome Trichobilharzia regenti in relation to host immune status

Authors

  • P. Kouřilová
    • Department of Tropical Medicine, 3rd Clinic of Infectious and Tropical DiseasesFaculty Hospital Bulovka
    • Department of Medical Microbiology, 3rd Faculty of MedicineCharles University
  • M. Syrůček
    • Department of PathologyHospital Na Homolce
    • National Reference Laboratory for Tissue HelminthosesInstitute for Postgraduate Medical Education
    • Department of Medical Microbiology, 3rd Faculty of MedicineCharles University
Original Paper

DOI: 10.1007/s00436-004-1079-7

Cite this article as:
Kouřilová, P., Syrůček, M. & Kolářová, L. Parasitol Res (2004) 93: 8. doi:10.1007/s00436-004-1079-7

Abstract

Cercariae of the nasal bird schistosome Trichobilharzia regenti are able to penetrate into mammalian skin and migrate to the mouse central nervous system (CNS) causing tissue injury in certain cases. Our study shows that the severity of T. regenti pathologies in the CNS closely depends on the host immune status. During the primary infection of immunocompetent mice, the parasites evoked an acute inflammatory reaction in the skin and the CNS involving focal oedema and cellular infiltration of the tissue. Challenge infections resulted in the development of extensive inflammatory foci in the host skin which precluded the subsequent migration of the schistosomula to the CNS. On the other hand, during primary as well as challenge infections of immunodeficient mice (SCID), no significant immune response against the parasites was detected in any of the host organs examined; however, in contrast to immunocompetent mice, the infections were frequently manifested by severe leg paralysis.

Copyright information

© Springer-Verlag 2004