Feline advantage heart™ (imidacloprid and moxidectin) topical solution as monthly treatment for prevention of heartworm infection (Dirofilaria immitis) and control of fleas (Ctenocephalides felis) on cats
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- Arther, R., Bowmann, D., McCall, J. et al. Parasitol Res (2003) 90(Suppl 3): S137. doi:10.1007/s00436-003-0917-3
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Imidacloprid applied monthly as a low volume topical application to cats provides highly effective flea control. Fleas are immobilized and killed after contact with imidacloprid on the dermis or hair of cats. Moxidectin is 100 % efficacious against pre-adult heartworm stages in dogs when administered orally or parentally in various formulations. Studies were conducted to evaluate flea control and heartworm prevention in cats with topically applied moxidectin and imidacloprid formulations. Moxidectin applied topically (1 mg/kg) was 100 % efficacious against experimental pre-adult D. immitis infections. Moxidectin solution alone had little or no activity against adult fleas (C. felis). Imidacloprid alone (10 mg /kg) had no activity against pre adult stages of D. immitis. Monthly topical treatment of cats with a combined formulation to provide 10 mg/kg imidacloprid + 1 mg/kg moxidectin provided 100 % prevention of D. immitis infection and >96 % control of adult fleas.