Original Paper

Parasitology Research

, Volume 88, Issue 6, pp 513-521

Variations in immunofluorescent antibody response against Trichobilharzia and Schistosoma antigens in compatible and incompatible hosts

  • P. KouřilováAffiliated withDepartment of Tropical Medicine, 3rd Clinic of Infectious and Tropical Diseases, Charles University, Faculty Hospital Bulovka, Studničkova 7, 128 43 Prague 2
  • , L. KolářováAffiliated withDepartment of Tropical Medicine, 3rd Clinic of Infectious and Tropical Diseases, Charles University, Faculty Hospital Bulovka, Studničkova 7, 128 43 Prague 2

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Abstract.

Schistosome cercariae are able to penetrate into the skin of various vertebrate hosts. However, in contrast to the compatible host, the infection of incompatible hosts results in the death of parasites at various intervals post-infection. In order to compare the immune responses in both types of host infected with Trichobilharzia regenti, Trichobilharzia szidati or Schistosoma mansoni, antibody responses against various T. regenti, T. szidati and S. mansoni schistosome developmental stages were studied. Indirect immunofluorescence tests (IFAT) demonstrated no species-specific reactivity of human, mouse or duck immune sera with cercarial surfaces. Study of the cercarial glands also gave no significant results. However, differences were found in schistosomular and adult antigens: only the sera of compatible hosts recognised schistosomular and adult gut associated antigens in homologous as well as heterologous systems. Based on the presented data, our study supports the use of IFAT for the serological differentiation of schistosomiasis and cercarial dermatitis caused by bird schistosomes.