Research in Experimental Medicine

, Volume 197, Issue 4, pp 177–187

Leukotriene receptor blockade in experimental heart failure

  • Michael Pfeifer
  • Frank Muders
  • Andreas Luchner
  • Friedrich Blumberg
  • Günter A. J. Riegger
  • Dietmar Elsner
Article

DOI: 10.1007/s004330050067

Cite this article as:
Pfeifer, M., Muders, F., Luchner, A. et al. Res. Exp. Med. (1997) 197: 177. doi:10.1007/s004330050067
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Abstract

The pathophysiological role of endogenous leukotrienes in cardiovascular control and the regulation of renal function in congestive heart failure is not known. Therefore, in six conscious dogs with or without heart failure induced by right ventricular pacing (270/min, 10 days) we studied the effects of the leukotriene receptor antagonist FPL55712 on hemodynamics, plasma hormones and renal function. In healthy dogs, FPL55712 (1 mg kg−1 + 0.01 mg kg−1 min−1 i. v.) had little effect on hemodynamics, only reducing heart rate by 11% and insignificantly increasing systemic vascular resistance. Plasma levels of norepinephrine (−57%), renin (−30%) and aldosterone (−24%) were significantly decreased. Renal function parameters were not changed. In dogs with heart failure, FPL55712 significantly increased systemic vascular resistance (+16%) and decreased cardiac output (−15%). Plasma hormone levels were not changed, but renal plasma flow was decreased (−13%) and glomerular filtration rate (+12%), renal vascular resistance (+13%) and filtration fraction (+23%) were increased. It is concluded that there is no evidence for a contribution of endogenous leukotrienes to the systemic vaso-constriction in experimental heart failure. Whether the increase in systemic and renal vascular resistance induced by the leukotriene antagonist in dogs with heart failure reflects a role for endogenous leukotrienes with vasodilator action is still unclear and deserves further investigation.

Key words

Heart failureLeukotrienesFPL55712Neurohormones

Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Michael Pfeifer
    • 1
  • Frank Muders
    • 1
  • Andreas Luchner
    • 1
  • Friedrich Blumberg
    • 1
  • Günter A. J. Riegger
    • 1
  • Dietmar Elsner
    • 1
  1. 1.Klinik und Poliklinik für Innere Medizin IIUniversitätsklinikumRegensburgGermany