Journal of Cancer Research and Clinical Oncology

, Volume 140, Issue 10, pp 1733–1738

Neoadjuvant therapy combined with a BMP regimen for treating penile cancer patients with lymph node metastasis: a retrospective study in China

  • Benkui Zou
  • Zengchi Han
  • Zhendan Wang
  • Jiasheng Bian
  • Jian Xu
  • Huansheng Wang
  • Mingshan Yang
  • Fajun Pei
  • Sheng Li
  • Zhonghua Xu
Review – Clinical Oncology

DOI: 10.1007/s00432-014-1720-5

Cite this article as:
Zou, B., Han, Z., Wang, Z. et al. J Cancer Res Clin Oncol (2014) 140: 1733. doi:10.1007/s00432-014-1720-5

Abstract

Background and aim

Combination chemotherapy is emerging in the management of advanced penile cancer. However, evidence-based chemotherapeutic regimens in the current guidelines are lacking. The aim of this study was to evaluate the efficacy of preoperative neoadjuvant chemotherapy combined with a BMP regimen including bleomycin (BLM), methopterin (MTX) and cisplatin (DDP) for treating advanced penile cancer patients.

Methods

We retrospectively audited the clinical and follow-up data of 24 penile cancer patients with fixed inguinal lymph node metastasis that were admitted in our hospital from 2001 to 2010 and received preoperative neoadjuvant chemotherapy.

Results

A total of 24 patients with advanced penile cancer (pN3) were recruited in this study. All patients received preoperative neoadjuvant chemotherapy combined with a BMP regimen. The average cycle of chemotherapy was two cycles (range 1–4 cycles). Among 24 adjuvant cases, 15 patients that responded to neoadjuvant chemotherapy underwent penectomy and inguinal lymphadenectomy. In contrast, nine cases did not respond to chemotherapy and received palliative local radiotherapy. Overall, the 1-, 2- and 5-year survival rates were 70.8, 50.0 and 45.8 %, respectively. The 5-year survival rate between the responder and non-responder groups was statistically significant (73.3 vs. 0 %, P < 0.001).

Conclusion

Neoadjuvant chemotherapy combined with a BMP regimen followed by surgery is beneficial to patients with advanced penile cancer.

Keywords

Penile cancer Inguinal lymph node metastasis Neoadjuvant chemotherapy Surgery 

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Benkui Zou
    • 1
    • 2
  • Zengchi Han
    • 1
  • Zhendan Wang
    • 3
  • Jiasheng Bian
    • 2
  • Jian Xu
    • 2
  • Huansheng Wang
    • 2
  • Mingshan Yang
    • 2
  • Fajun Pei
    • 3
  • Sheng Li
    • 4
  • Zhonghua Xu
    • 1
  1. 1.Department of Urology, Qilu HospitalShandong UniversityJinanChina
  2. 2.Department of UrologyTumor Hospital of Shandong ProvinceJinanChina
  3. 3.Shandong Academy of Medical ScienceUniversity of JinanJinanChina
  4. 4.Department of Hepatology, Tumor Hospital of Shandong ProvinceShandong Academy of Medical ScienceJinanChina

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