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Adiponectin receptor expression in gastric carcinoma: implications in tumor development and progression

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Abstract

Purpose

Adiponectin, an adipocyte-secreted endogenous insulin sensitizer, appears to play an important role in progression of several malignancies. Expression of adiponectin receptors—AdipoR1 and AdipoR2—has been documented in gastric cancer (GC) cell lines, but its role in GCs is still controversial. We investigated expression level of 2 adiponectin receptors and correlated their expression with prognosis in GC patients.

Methods

We immunohistochemically evaluated AdipoR1 and AdipoR2 expression in 59 non-neoplastic gastric mucosas, 48 gastric adenomas, 250 GCs, and 58 lymph nodes involved by metastatic GC and assessed its association with clinicopathologic characteristics.

Results

Expression rates of both receptors increased stepwise in non-neoplastic gastric mucosa, gastric adenoma, intestinal-type GC, and metastatic GC (p < 0.001). AdipoR1 and AdipoR2 expression was observed in 85 (34.0 %) and 118 (47.2 %) GC cases, respectively. Expression rates were higher in intestinal-type GC than in diffuse-type GC (p < 0.001 and 0.016, respectively). AdipoR1 and AdipoR2 expression was more frequent in advanced GC than in early GC (p < 0.001, each) and was associated with lymphatic invasion (p = 0.046 and 0.001, respectively). AdipoR2 expression was associated with poor overall and disease-free survival (p = 0.001 and 0.007, respectively). AdipoR1 expression was associated with poor disease-free survival for intestinal-type GC patients (p = 0.046). In multivariate analysis, AdipoR2 was an independent prognostic factor for intestinal-type GC (p = 0.017).

Conclusions

Adiponectin receptor expression is related to GC development and progression, especially intestinal-type GC. Thus, adiponectin receptor expression can serve as a prognostic marker in GC patients.

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Acknowledgments

This study was supported by grant no. 11-2012-008 from the Seoul National University Bundang Hospital Research Fund.

Conflict of interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Pathology, Seoul National University Bundang Hospital, 173-82 Gumiro, Bundang-gu, Seongnam, Gyeonggi, 463-707, South Korea

    Eun Shin, Gheeyoung Choe & Hye Seung Lee

  2. Department of Surgery, Seoul National University Bundang Hospital, 173-82 Gumiro, Bundang-gu, Seongnam, Gyeonggi, 463-707, South Korea

    Do Joong Park & Hyung-Ho Kim

  3. Department of Pathology, College of Medicine, Korea University, 126-1 Anam-dong 5 ga, Seongbuk-gu, Seoul, 163-705, South Korea

    Nam Hee Won

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  1. Eun Shin
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  2. Do Joong Park
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  5. Gheeyoung Choe
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Correspondence to Hye Seung Lee.

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Shin, E., Park, D.J., Kim, HH. et al. Adiponectin receptor expression in gastric carcinoma: implications in tumor development and progression. J Cancer Res Clin Oncol 139, 709–718 (2013). https://doi.org/10.1007/s00432-013-1379-3

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