Journal of Cancer Research and Clinical Oncology

, Volume 139, Issue 4, pp 709–718

Adiponectin receptor expression in gastric carcinoma: implications in tumor development and progression

  • Eun Shin
  • Do Joong Park
  • Hyung-Ho Kim
  • Nam Hee Won
  • Gheeyoung Choe
  • Hye Seung Lee
Original Paper

DOI: 10.1007/s00432-013-1379-3

Cite this article as:
Shin, E., Park, D.J., Kim, HH. et al. J Cancer Res Clin Oncol (2013) 139: 709. doi:10.1007/s00432-013-1379-3

Abstract

Purpose

Adiponectin, an adipocyte-secreted endogenous insulin sensitizer, appears to play an important role in progression of several malignancies. Expression of adiponectin receptors—AdipoR1 and AdipoR2—has been documented in gastric cancer (GC) cell lines, but its role in GCs is still controversial. We investigated expression level of 2 adiponectin receptors and correlated their expression with prognosis in GC patients.

Methods

We immunohistochemically evaluated AdipoR1 and AdipoR2 expression in 59 non-neoplastic gastric mucosas, 48 gastric adenomas, 250 GCs, and 58 lymph nodes involved by metastatic GC and assessed its association with clinicopathologic characteristics.

Results

Expression rates of both receptors increased stepwise in non-neoplastic gastric mucosa, gastric adenoma, intestinal-type GC, and metastatic GC (p < 0.001). AdipoR1 and AdipoR2 expression was observed in 85 (34.0 %) and 118 (47.2 %) GC cases, respectively. Expression rates were higher in intestinal-type GC than in diffuse-type GC (p < 0.001 and 0.016, respectively). AdipoR1 and AdipoR2 expression was more frequent in advanced GC than in early GC (p < 0.001, each) and was associated with lymphatic invasion (p = 0.046 and 0.001, respectively). AdipoR2 expression was associated with poor overall and disease-free survival (p = 0.001 and 0.007, respectively). AdipoR1 expression was associated with poor disease-free survival for intestinal-type GC patients (p = 0.046). In multivariate analysis, AdipoR2 was an independent prognostic factor for intestinal-type GC (p = 0.017).

Conclusions

Adiponectin receptor expression is related to GC development and progression, especially intestinal-type GC. Thus, adiponectin receptor expression can serve as a prognostic marker in GC patients.

Keywords

Gastric carcinoma Adiponectin receptor Prognosis Immunohistochemistry 

Supplementary material

432_2013_1379_MOESM1_ESM.doc (86 kb)
Supplementary material 1 (DOC 86 kb)
432_2013_1379_MOESM2_ESM.doc (2.2 mb)
Supplementary material 2 (DOC 2208 kb)
432_2013_1379_MOESM3_ESM.doc (2.5 mb)
Supplementary material 3 (DOC 2599 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Eun Shin
    • 1
  • Do Joong Park
    • 2
  • Hyung-Ho Kim
    • 2
  • Nam Hee Won
    • 3
  • Gheeyoung Choe
    • 1
  • Hye Seung Lee
    • 1
  1. 1.Department of PathologySeoul National University Bundang HospitalSeongnamSouth Korea
  2. 2.Department of SurgerySeoul National University Bundang HospitalSeongnamSouth Korea
  3. 3.Department of Pathology, College of MedicineKorea UniversitySeongbuk-gu, SeoulSouth Korea