Challenging the effectiveness of green tea in primary and tertiary cancer prevention
- Hirota FujikiAffiliated withFaculty of Pharmaceutical Sciences, Tokushima Bunri University Email author
- , Kazue ImaiAffiliated withDepartment of Radiobiology and Molecular Epidemiology, Radiation Effects Research Foundation
- , Kei NakachiAffiliated withDepartment of Radiobiology and Molecular Epidemiology, Radiation Effects Research Foundation
- , Masahito ShimizuAffiliated withDepartment of Medicine, Gifu University Graduate School of Medicine
- , Hisataka MoriwakiAffiliated withDepartment of Medicine, Gifu University Graduate School of Medicine
- , Masami SuganumaAffiliated withResearch Institute for Clinical Oncology, Saitama Cancer Center
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Drinking green tea daily is part of Japanese culture, and various studies have revealed that green tea is a cancer preventive. We here review our progress in cancer prevention with green tea on 12 main topics, from basic to clinical level.
Topics and methods
Biochemical and biological studies of green tea catechins, a prospective cohort study, preclinical safety trials with tablets of green tea extract, double-blind randomized clinical phase II prevention trial for recurrence of colorectal adenomas, and synergistically enhanced inhibition by the combination of green tea catechins and anticancer drugs. All results were significant, including human studies with informed consent.
Drinking 10 Japanese-size cups of green tea per day delayed the cancer onset of humans 7 years for females. For tertiary cancer prevention, consuming 10 cups of green tea per day fortified by green tea tablets, 50 %, significantly prevented the recurrence of colorectal adenomas. A minimum effective amount of green tea catechins for cancer prevention was found in humans. In addition, the combination of green tea catechins and anticancer drugs engendered a new cancer therapeutic strategy.
The consumption of 10 Japanese-size cups of green tea per day is a significant factor in primary cancer prevention for the general population, and the preventive effect on recurrence of colorectal adenomas in patients is vital evidence in tertiary cancer prevention.
KeywordsApoptosis Delayed cancer onset GADD153 Green tea tablet Phase II prevention trial Prospective cohort study TNF-α
- Challenging the effectiveness of green tea in primary and tertiary cancer prevention
Journal of Cancer Research and Clinical Oncology
Volume 138, Issue 8 , pp 1259-1270
- Cover Date
- Print ISSN
- Online ISSN
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- Delayed cancer onset
- Green tea tablet
- Phase II prevention trial
- Prospective cohort study
- Industry Sectors
- Author Affiliations
- 1. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, 770-8514, Japan
- 2. Department of Radiobiology and Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, 732-0815, Japan
- 3. Department of Medicine, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan
- 4. Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, 362-0806, Japan