Journal of Cancer Research and Clinical Oncology

, Volume 138, Issue 4, pp 627–635

Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma

Authors

  • Songlin Piao
    • Department of Oral and Maxillofacial SurgeryThe First Affiliated Hospital of Harbin Medical University
  • Shu Zhao
    • Department of Medical OncologyThe Third Affiliated Hospital of Harbin Medical University
  • Fulin Guo
    • Department of Oral and Maxillofacial SurgeryThe First Affiliated Hospital of Harbin Medical University
  • Jie Xue
    • Department of Oral and Maxillofacial SurgeryThe First Affiliated Hospital of Harbin Medical University
  • Guodong Yao
    • Department of Medical PathologyThe Third Affiliated Hospital of Harbin Medical University
  • Zhili Wei
    • Department of Oral and Maxillofacial SurgeryThe Second Affiliated Hospital of Harbin Medical University
  • Qi Huang
    • Center of MorphologyHarbin Medical University
  • Yao Sun
    • Hard Tissue LabThe Second Affiliated Hospital of Harbin Medical University
    • Department of Oral and Maxillofacial SurgeryThe Second Affiliated Hospital of Harbin Medical University
    • Hard Tissue LabThe Second Affiliated Hospital of Harbin Medical University
Original Paper

DOI: 10.1007/s00432-011-1142-6

Cite this article as:
Piao, S., Zhao, S., Guo, F. et al. J Cancer Res Clin Oncol (2012) 138: 627. doi:10.1007/s00432-011-1142-6

Abstract

Purpose

The aim of this study was to investigate expression of CD147 and MMP-9 in salivary duct carcinoma (SDC) so as to determine whether these two genes may be correlated with poor prognosis of SDC.

Methods

We examined the significance of the CD147 and MMP-9 expression in SDC (n = 35), non-cancerous salivary tissue (n = 20) in previously untreated patients using immunohistochemical staining. Furthermore, we analyzed the correlation between the expression of these two genes and various clinicopathologic factors including survival status of patients with SDC.

Results

Positive stain of CD147 and MMP-9 was seen in all 35 cases of tumor samples. A statistical correlation was observed between CD147 and MMP-9 expression in SDC tissues. The incidences of high expression were 45.71% for CD147 and 51.43% for MMP-9 in 35 SDC tissues, respectively. High expression of CD147 and MMP-9 was significantly correlated with clinical feature and shorter progression-free survival (PFS) (PCD147 = 0.031; PMMP-9 = 0.020) and overall survival (OS) (PCD147 = 0.044; PMMP-9 = 0.013).

Conclusion

CD147 and MMP-9 expression is correlated with invasion, metastasis and shorter PFS/OS of SDC. Patients with high expression of CD147 and MMP-9 had poor prognosis than SDC patients with low expression.

Keywords

CD147MMP-9Salivary duct carcinomaCancer prognosisMetastasis

Copyright information

© Springer-Verlag 2012