Original Paper

Journal of Cancer Research and Clinical Oncology

, Volume 137, Issue 7, pp 1085-1093

18F-FDG PET or PET-CT to evaluate prognosis for head and neck cancer: a meta-analysis

  • Peng XieAffiliated withDepartment of Radiation Oncology, Shandong Tumor Hospital and Institute, Key Laboratory of Radiation Oncology of Shandong Province
  • , Minghuan LiAffiliated withDepartment of Radiation Oncology, Shandong Tumor Hospital and Institute, Key Laboratory of Radiation Oncology of Shandong Province
  • , Hanxi ZhaoAffiliated withDepartment of Radiation Oncology, Shandong Tumor Hospital and Institute, Key Laboratory of Radiation Oncology of Shandong Province
  • , Xindong SunAffiliated withDepartment of Radiation Oncology, Shandong Tumor Hospital and Institute, Key Laboratory of Radiation Oncology of Shandong Province
  • , Zheng FuAffiliated withDepartment of Radiation Oncology, Shandong Tumor Hospital and Institute, Key Laboratory of Radiation Oncology of Shandong Province
  • , Jinming YuAffiliated withDepartment of Radiation Oncology, Shandong Tumor Hospital and Institute, Key Laboratory of Radiation Oncology of Shandong Province Email author 

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Abstract

Purpose

The purpose of this meta-analysis was to evaluate the prognostic value of standard uptake value (SUV) from serial Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with head and neck cancer.

Methods

We searched for articles limited to head and neck cancer, dealt with the impact of SUV on survival and published in English. The endpoints were disease-free survival (DFS), overall survival (OS), and local control (LC). Two reviewers extracted data independently.

Results

Thirty-five studies were identified; of which, 26 studies involving 1,415 patients met the inclusion criteria. Pooled survival data suggested better DFS, OS, and LC in patients with low SUV of pre-treatment, and the odds ratio (OR) was 0.23, 0.24, and 0.27, respectively. Patients having tumors with low SUV of post-treatment also had significantly better DFS (OR = 0.17) and OS (OR = 0.28) than those with high SUV.

Conclusions

The present meta-analysis showed that 18F-FDG uptake, as measured by the SUV before treatment and metabolic response after treatment, are valuable for predicting long-term survival in head and neck cancer. High 18F-FDG uptake may be useful for identifying patients requiring more aggressive treatment.

Keywords

18F-FDG Head and neck cancer Standard uptake value Prognosis Meta-analysis