Journal of Cancer Research and Clinical Oncology

, Volume 136, Issue 12, pp 1853–1859

A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population

Authors

  • Tonghai Dou
    • Department of Microbiology School of Life SciencesFudan University
  • Qihan Wu
    • Department of Biomedicine, School of Life ScienceEast China Normal University
  • Xin Chen
    • Department of Biomedicine, School of Life ScienceEast China Normal University
  • Judit Ribas
    • The James Buchanan Brady Urological InstituteJohns Hopkins University School of Medicine
  • Xiaohua Ni
    • The James Buchanan Brady Urological InstituteJohns Hopkins University School of Medicine
  • Cheng Tang
    • Department of Biomedicine, School of Life ScienceEast China Normal University
    • Neurosurgery Department of Huashan HospitalFudan University
  • Liangfu Zhou
    • Neurosurgery Department of Huashan HospitalFudan University
    • Department of Biomedicine, School of Life ScienceEast China Normal University
    • State Key Laboratory of Genetic Engineering, Center for Fudan-VARI Genetics Epidemiology and MOE Key Laboratory of Contemporary Anthropology, School of Life SciencesFudan University
Original Paper

DOI: 10.1007/s00432-010-0844-5

Cite this article as:
Dou, T., Wu, Q., Chen, X. et al. J Cancer Res Clin Oncol (2010) 136: 1853. doi:10.1007/s00432-010-0844-5

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in regulation of eukaryotic gene expression. Aberrant expression and structural alternation of miRNAs are considered to participate in tumorigenesis and cancer development. Recently, different genotypes of miR-196a polymorphisms (SNP, rs11614913) were found to be associated with the survival of patients with lung cancer and increased risk of breast cancer. To further investigate whether this polymorphism may influence glioma risk or not, we examined the SNP allele frequency in Chinese population. Our data shows the genotype CC of miR-196a (rs11614913) polymorphism is associated with decreased risk of glioma in the Chinese population (OR = 0.74, 95% CI:0.56–0.98). Furthermore, a significant association was observed between this genotype and glioma risk in the subgroups of adult glioma (OR = 0.73, 95% CI:0.55–0.98), male glioma (OR = 0.69, 95% CI:0.48–0.99) and patients with glioblastoma (OR = 0.58, 95% CI:0.37–0.91). This was the first study investigating the association between the miR-196a rs11614913 and glioma risk. Compared with the results from previous studies in lung cancer and breast cancer, our data suggest a different genotype association in glioma. This may be related to the diversity on the tissue origin, tumor type, tumorigenesis, and developing process.

Keywords

microRNAPolymorphismGliomaGenetic variation

Copyright information

© Springer-Verlag 2010