Original Paper

Journal of Cancer Research and Clinical Oncology

, Volume 136, Issue 12, pp 1839-1844

First online:

Diagnostic dilemma of abdominopelvic tuberculosis:a series of 20 cases

  • Xia XiAffiliated withCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • , Li ShuangAffiliated withCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • , Wang DanAffiliated withCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • , Hu TingAffiliated withCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • , Meng Yu HanAffiliated withCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • , Cao YingAffiliated withCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • , Mei QuanAffiliated withCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • , Sun ChaoYangAffiliated withCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • , Chen ZhiLanAffiliated withCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
    • , Feng CuiAffiliated withCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
    • , Cao MingAffiliated withCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
    • , Jian Feng ZhouAffiliated withCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
    • , Wang Shi XuanAffiliated withCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
    • , Yun Ping LuAffiliated withCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
    • , Ding MaAffiliated withCancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Email author 

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Abstract

Objective

To establish more effective diagnostic procedures to identify the characteristic features of abdominopelvic tuberculosis (APTB) mimicking advanced ovarian cancer.

Methods

A retrospective review of 20 cases of APTB mimicking advanced ovarian cancer was undertaken.

Results

The mean age of the patients was 28.9 ± 10.8 years. The main clinical manifestations were abdominal pain (45%) and distention (45%). CA125 level was elevated in 18 cases (90.0%). Pelvic mass in 18 patients (90.0%) and ascites in 12 patients (60.0%) were detected by using abdominal US. The bacteriologic cultures and cytological studies were all negative (10 cases, 100%). Laparotomy (17 cases) and laparoscopic evaluation (1 case) was performed with the presumptive diagnosis of advanced ovarian cancer except for 2 patients treated with diagnostic anti-TB chemotherapy. The common intra-operative findings were miliary nodules (14 cases, 77.8%) and widespread adhesion (10 cases, 55.6%). Intra-operative frozen section was obtained in 10 cases, and the typical tuberculosis tubercles were detected in all cases.

Conclusion

APTB should be considered in all cases with pelvic mass, ascites and high levels of CA125, although clinical features and laboratory results specifically indicate neither ovarian malignancy nor APTB. Diagnostic laparotomy is a direct and safe method. To avoid extended surgery, the cases with APTB can be diagnosed through intra-operative frozen section in conjunction with clinical features.

Keywords

Abdominopelvic tuberculosis Ovarian cancer Diagnosis Laparotomy Frozen section