Journal of Cancer Research and Clinical Oncology

, Volume 135, Issue 10, pp 1421–1428

Serum soluble Fas level determines clinical outcome of patients with diffuse large B-cell lymphoma treated with CHOP and R-CHOP

Authors

  • Takeshi Hara
    • First Department of Internal MedicineGifu University Graduate School of Medicine
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Naoe Goto
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Nobuhiro Kanemura
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Takeshi Yoshikawa
    • Division of HematologyGifu Municipal Hospital
  • Senji Kasahara
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Toshiki Yamada
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Michio Sawada
    • Department of HematologyGifu Red-Cross Hospital
  • Hideko Goto
    • Department of Internal MedicineKisogawa Municipal Hospital
  • Kenji Fukuno
    • Department of HematologyGifu Red-Cross Hospital
  • Jun-ichi Kitagawa
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Ichiro Yasuda
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Naoki Katsumura
    • First Department of Internal MedicineGifu University Graduate School of Medicine
  • Masao Takemura
    • Department of Informative Clinical MedicineGifu University Graduate School of Medicine
  • Takeshi Takahashi
    • Division of HematologyGifu Municipal Hospital
  • Tsuyoshi Takami
    • Department of ImmunopathologyGifu University Graduate School of Medicine
  • Hisataka Moriwaki
    • First Department of Internal MedicineGifu University Graduate School of Medicine
Original Paper

DOI: 10.1007/s00432-009-0586-4

Cite this article as:
Hara, T., Tsurumi, H., Goto, N. et al. J Cancer Res Clin Oncol (2009) 135: 1421. doi:10.1007/s00432-009-0586-4

Abstract

Introduction

We previously reported that serum concentrations of soluble Fas (sFas) predict the clinical outcome of patients with diffuse large B cell lymphoma (DLBCL) after treatment with CHOP but without rituximab (R). Here, we investigated whether the role of sFas as a prognostic factor remains valid in the R-CHOP era.

Patients

We treated 132 patients with DLBCL between October 1995 and September 2002 (group A: without rituximab), and 75 between December 2002 and March 2007 (group B: with rituximab). The patients received eight cycles of CHOP or THP (tetrahydropyranyl-adriamycin)-COP before September 2002, and R-CHOP or R-THP-COP after October 2002. The distribution of patients according to the International Prognostic Index did not significantly differ between the groups.

Results

The 5-year overall survival (OS) rates for patients with sFas levels of ≥3.0 and <3.0 ng/ml in group A were 19.8 and 61.9% (P < 0.0001), whereas the 3-year OS rates in group B were 54.7 and 92.2% (P < 0.01), respectively. Multivariate analysis using the proportional hazards model revealed that sFas most significantly correlated with overall survival (P < 0.05).

Conclusion

Serum sFas is thus a useful tool for selecting the appropriate therapeutic strategy for DLBCL.

Keywords

Diffuse large B-cell lymphoma (DLBCL)Soluble Fas (sFas)Prognostic analysisRevised International Prognostic Index

Copyright information

© Springer-Verlag 2009