Date: 12 Feb 2009
Predictive value of telomerase reverse transcriptase expression in patients with high risk superficial bladder cancer treated with adjuvant BCG immunotherapy
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We conducted a prospective study to determine whether expression of telomerase reverse transcriptase (hTERT) is associated with recurrence-free-survival (RFS) or development of invasive disease in patients with high risk superficial bladder cancer (SBC) that received adjuvant BCG immunotherapy.
Thirty patients with high-grade T1 tumors were evaluated. Pre-BCG TURBT and post-BCG specimens were analyzed for hTERT nucleolar expression by immunohistochemistry.
Post-BCG hTERT expression was statistically significantly lower than pre-BCG hTERT expression. Pre-BCG hTERT nucleolar staining in more than 75% of cells was associated with worse RFS (9 months vs. not yet reached, P = 0.05), while post-BCG hTERT nucleolar staining in more than 50% of the cells was associated with worse RFS (6 months vs. not yet reached, P = 0.001) and development of invasive disease. In multivariate analysis, post-BCG hTERT expression was independently associated with RFS and development of invasive disease.
Immunohistochemical evaluation of hTERT may help define a subset of high risk SBC patients that will eventually fail BCG and may therefore benefit from early salvage cystectomy.
I. Zachos and P. A. Konstantinopoulos contributed equally to this work.
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- Predictive value of telomerase reverse transcriptase expression in patients with high risk superficial bladder cancer treated with adjuvant BCG immunotherapy
Journal of Cancer Research and Clinical Oncology
Volume 135, Issue 9 , pp 1169-1175
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- Superficial bladder cancer
- Telomerase reverse transcriptase
- Multivariate analysis
- Industry Sectors
- Author Affiliations
- 1. Department of Urology, University of Thessalia, Larissa, Greece
- 2. Department of Biological Chemistry, Medical School, University of Athens, 75, M. Asias Street, 11527, Athens, Greece
- 3. Division of Hematology, Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
- 4. Department of Pathology, ‘Agios Andreas’ Hospital, Patras, Greece
- 5. Second Department of Urology, ‘Sismanoglio’ General Hospital, University of Athens, Athens, Greece
- 6. Department of Urology, ‘Agios Andreas’ Hospital, Patras, Greece
- 7. Department of General Surgery, ‘Laiko’ General Hospital, Medical School, University of Athens, Athens, Greece