, Volume 135, Issue 3, pp 485-490
Date: 26 Sep 2008

The prevalence of microsatellite instability in head and neck squamous cell carcinoma

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Abstract

Purpose

The present study aimed to use the most definitive available techniques to resolve controversy in the literature as to the prevalence of microsatellite instability (MSI) in head and neck squamous cell carcinoma (HNSCC).

Methods

Eighty patients with advanced HNSCC were enrolled in the study that examined 20 microsatellite markers with automatic fragment analysis. These markers included ones derived from the NCI reference panel and ones previously reported to detect MSI in HNSCC (HNSCC panel).

Results

Only one of 80 tumors could be considered positive for MSI. For this case, both panels showed MSI-High (8/10 positive markers for the NCI reference panel and 6/10 positive markers for the HNSCC panel). Qualitatively, the observed MSI could be classified as Type B MSI.

Conclusions

The present results indicate that MSI has a low prevalence in HNSCC.