The prevalence of microsatellite instability in head and neck squamous cell carcinoma
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The present study aimed to use the most definitive available techniques to resolve controversy in the literature as to the prevalence of microsatellite instability (MSI) in head and neck squamous cell carcinoma (HNSCC).
Eighty patients with advanced HNSCC were enrolled in the study that examined 20 microsatellite markers with automatic fragment analysis. These markers included ones derived from the NCI reference panel and ones previously reported to detect MSI in HNSCC (HNSCC panel).
Only one of 80 tumors could be considered positive for MSI. For this case, both panels showed MSI-High (8/10 positive markers for the NCI reference panel and 6/10 positive markers for the HNSCC panel). Qualitatively, the observed MSI could be classified as Type B MSI.
The present results indicate that MSI has a low prevalence in HNSCC.
- The prevalence of microsatellite instability in head and neck squamous cell carcinoma
Journal of Cancer Research and Clinical Oncology
Volume 135, Issue 3 , pp 485-490
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- Head and neck neoplasms
- Squamous cell carcinoma
- Microsatellite repeats
- Capillary electrophoresis
- Industry Sectors
- Author Affiliations
- 1. Laboratory of Experimental Radiotherapy, Leuvens Kanker Instituut, UH Gasthuisberg, Herestraat 49, 3000, Louvain, Belgium
- 2. Center for Human Genetics, UH Gasthuisberg, Herestraat 49, 3000, Louvain, Belgium
- 3. Department of Otorhinolaryngology, Head and Neck Surgery, UH Leuven, UH St Rafael, Kapucijnenvoer 33, 3000, Louvain, Belgium
- 4. Department of Pathology, UH Gasthuisberg, Herestraat 49, 3000, Louvain, Belgium
- 5. Department of Radiotherapy, UH Gasthuisberg, CDG, 8th floor, Box 815, 3000, Louvain, Belgium