Journal of Cancer Research and Clinical Oncology

, 135:439

Tumor-infiltrating macrophages can predict favorable prognosis in hepatocellular carcinoma after resection

Authors

  • Yi-Wei Li
    • Liver Cancer Institute, Zhong Shan Hospital and Institutes of Biomedical Sciences, Shanghai Medical SchoolFudan University
  • Shuang-Jian Qiu
    • Liver Cancer Institute, Zhong Shan Hospital and Institutes of Biomedical Sciences, Shanghai Medical SchoolFudan University
    • Liver Cancer Institute, Zhong Shan Hospital and Institutes of Biomedical Sciences, Shanghai Medical SchoolFudan University
  • Qiang Gao
    • Liver Cancer Institute, Zhong Shan Hospital and Institutes of Biomedical Sciences, Shanghai Medical SchoolFudan University
  • Jian Zhou
    • Liver Cancer Institute, Zhong Shan Hospital and Institutes of Biomedical Sciences, Shanghai Medical SchoolFudan University
  • Yong-Sheng Xiao
    • Liver Cancer Institute, Zhong Shan Hospital and Institutes of Biomedical Sciences, Shanghai Medical SchoolFudan University
  • Yang Xu
    • Liver Cancer Institute, Zhong Shan Hospital and Institutes of Biomedical Sciences, Shanghai Medical SchoolFudan University
  • Xiao-Ying Wang
    • Liver Cancer Institute, Zhong Shan Hospital and Institutes of Biomedical Sciences, Shanghai Medical SchoolFudan University
  • Jian Sun
    • Liver Cancer Institute, Zhong Shan Hospital and Institutes of Biomedical Sciences, Shanghai Medical SchoolFudan University
  • Xiao-Wu Huang
    • Liver Cancer Institute, Zhong Shan Hospital and Institutes of Biomedical Sciences, Shanghai Medical SchoolFudan University
Original Paper

DOI: 10.1007/s00432-008-0469-0

Cite this article as:
Li, Y., Qiu, S., Fan, J. et al. J Cancer Res Clin Oncol (2009) 135: 439. doi:10.1007/s00432-008-0469-0

Abstract

Purpose

To evaluate the prognostic value of tumor-associated macrophages (TAM), individually or synergistically with CD45RO + memory T cells (TM), in hepatocellular carcinoma (HCC) patients following resection.

Methods

The infiltration of TAM and TM was assessed by immunohistochemistry in tissue microarray containing 302 HCC specimens. Correlations between TAM/TM infiltration and clinicopathologic features, disease-free survival (DFS) and overall survival (OS) were statistically analyzed.

Results

High TAM infiltration was associated with both improved DFS (P = 0.0021) and OS (P = 0.0481). Multivariate analysis identified TAM infiltration as independent prognostic factor for DFS (P = 0.004) and OS (P = 0.049). A second analysis clarified the synergistic effect of TAM&TM infiltration for DFS (P = 0.004) and OS (P = 0.040).

Conclusions

Both TAM infiltration alone and concomitant infiltration of TAM&TM are associated with improved DFS/OS, suggesting that TAM could protect HCC patients from recurrence/metastasis and prolong survival by distinct mechanisms.

Keywords

Tumor-associated macrophages (TAM)CD45RO + T cell (TM)Hepatocellular carcinoma (HCC)Prognosis

Abbreviations

HCC

Hepatocellular carcinoma

TAM

Tumor-associated macrophages

TM

CD45RO + T cell

TNM

Tumor-node-metastasis

TACE

Transcatheter arterial chemoembolization

OS

Overall survival

DFS

Disease-free survival

AFP

Alpha-fetoprotein

Supplementary material

432_2008_469_MOESM1_ESM.doc (82 kb)
Electronic supplementary material Appendix Table 5 and 6 (DOC 82 kb)

Copyright information

© Springer-Verlag 2008