Tumor-infiltrating macrophages can predict favorable prognosis in hepatocellular carcinoma after resection
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- Li, YW., Qiu, SJ., Fan, J. et al. J Cancer Res Clin Oncol (2009) 135: 439. doi:10.1007/s00432-008-0469-0
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To evaluate the prognostic value of tumor-associated macrophages (TAM), individually or synergistically with CD45RO + memory T cells (TM), in hepatocellular carcinoma (HCC) patients following resection.
The infiltration of TAM and TM was assessed by immunohistochemistry in tissue microarray containing 302 HCC specimens. Correlations between TAM/TM infiltration and clinicopathologic features, disease-free survival (DFS) and overall survival (OS) were statistically analyzed.
High TAM infiltration was associated with both improved DFS (P = 0.0021) and OS (P = 0.0481). Multivariate analysis identified TAM infiltration as independent prognostic factor for DFS (P = 0.004) and OS (P = 0.049). A second analysis clarified the synergistic effect of TAM&TM infiltration for DFS (P = 0.004) and OS (P = 0.040).
Both TAM infiltration alone and concomitant infiltration of TAM&TM are associated with improved DFS/OS, suggesting that TAM could protect HCC patients from recurrence/metastasis and prolong survival by distinct mechanisms.
KeywordsTumor-associated macrophages (TAM) CD45RO + T cell (TM) Hepatocellular carcinoma (HCC) Prognosis
CD45RO + T cell
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