Journal of Cancer Research and Clinical Oncology

, Volume 134, Issue 6, pp 653–658

Kaposi’s sarcoma after liver transplantation

  • Fabrizio Di Benedetto
  • Stefano Di Sandro
  • Nicola De Ruvo
  • Massimiliano Berretta
  • Michele Masetti
  • Roberto Montalti
  • Roberto Ballarin
  • Stefania Cocchi
  • Leonardo Potenza
  • Mario Luppi
  • Giorgio E. Gerunda
Original Paper

DOI: 10.1007/s00432-007-0329-3

Cite this article as:
Di Benedetto, F., Di Sandro, S., De Ruvo, N. et al. J Cancer Res Clin Oncol (2008) 134: 653. doi:10.1007/s00432-007-0329-3

Abstract

Introduction

Kaposi’s Sarcoma (KS) is a malignant neoplasm arising from endothelial cells. HHV8-infection represents a key pathogenic determinant for the development of KS. There are no standard criteria to treat KS in immunosuppressed-individuals. Six cases (2.1%) of KS occurred in our Center among 285-recipients who underwent liver transplantation (LT) between October 2000 and November 2006.

Methods

Patients were four males and two females. Mean age was 57 years (range 44–65). Indication for LT was ESLD associated/non-associated with hepatocellular carcinoma (HCC). The immunosuppressive regimen consisted of cyclosporine/tacrolimus associated with steroids or daclizumab. HHV8-detection was performed by the serological method before LT, and by polymerase chain reaction (PCR)-analysis after KS.

Results

One patient had HCV-related cirrhosis and coinfection from HIV, three had HBV-related cirrhosis, two of these with coexistent HCC. The last two patients had alcoholic-cirrhosis, one with coexistent HCC. Mean time from transplantation to KS was 6.2 months (range 3.8–8.8). Three patients were treated with doxorubicin and three with switch from calcineurin-inhibitors to sirolimus. Three patients expired after 11.5, 8.8, and 7.4 months from KS diagnosis.

Discussion

KS should be treated by a multidisciplinary approach to obtain an early diagnosis and best management. Effective treatment with immunosuppression reduction or switch to sirolimus is mandatory and can induce complete regression.

Keywords

Liver transplantationKaposi’s sarcomaHHV8 coinfection

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Fabrizio Di Benedetto
    • 1
  • Stefano Di Sandro
    • 1
  • Nicola De Ruvo
    • 1
  • Massimiliano Berretta
    • 2
  • Michele Masetti
    • 1
  • Roberto Montalti
    • 1
  • Roberto Ballarin
    • 1
  • Stefania Cocchi
    • 3
  • Leonardo Potenza
    • 4
  • Mario Luppi
    • 4
  • Giorgio E. Gerunda
    • 1
  1. 1.Liver and Multivisceral Transplant CenterUniversity of Modena and Reggio EmiliaModenaItaly
  2. 2.Division of Medical Oncology ANational Cancer Institute, Centro di Riferimento OncologicoAvianoItaly
  3. 3.Department of Internal Medicine and Medical Specialties Infectious Diseases ClinicUniversity of Modena and Reggio EmiliaModenaItaly
  4. 4.Section of Haematology, Department of Oncology and HaematologyUniversity of Modena and Reggio EmiliaModenaItaly