Journal of Cancer Research and Clinical Oncology

, Volume 134, Issue 2, pp 187–192

Palliative gastrectomy and chemotherapy for stage IV gastric cancer

  • Sheng-Zhang Lin
  • Hong-Fei Tong
  • Tao You
  • Yao-Jun Yu
  • Wei-Jun Wu
  • Cong Chen
  • Wei Zhang
  • Bing Ye
  • Chun-Ming Li
  • Zhi-Qiang Zhen
  • Jia-Rong Xu
  • Jun-Liang Zhou
Original Paper

DOI: 10.1007/s00432-007-0268-z

Cite this article as:
Lin, SZ., Tong, HF., You, T. et al. J Cancer Res Clin Oncol (2008) 134: 187. doi:10.1007/s00432-007-0268-z

Abstract

Purpose

To investigate the value of palliative gastrectomy and chemotherapy in a large series of patients with stage IV gastric cancer.

Methods

A total of 389 patients were identified in survival analysis. Among which, 183 cases received palliative gastrectomy (PG) and 206 cases received unresectable operation, 184 cases received palliative chemotherapy (PC) and 205 cases did not receive chemotherapy. The survival advantages of patients, based on treatments modality, were also analyzed in patients with liver metastasis, peritoneal dissemination and lymph node metastasis.

Results

The 1-year, 3-year, 5-year survival rate of those patients who were treated with PG + PC were 85.7% (96/112), 32.1% (36/112), and 8.9% (10/112), which were far better than those who were not. For those patients with liver metastasis, peritoneal dissemination, and/or N3 lymph node metastasis, survival advantages were also present if treated with this multimodality approach.

Conclusion

The survival time and palliative duration were significantly longer in patients after PG than after non-resection operations. Postoperative chemotherapy prolonged the survival time of patients after palliative surgery. PG combined with adjuvant chemotherapy may improve survival in patients with stage IV gastric cancer, even with liver metastasis, peritoneal dissemination, and lymph node metastasis.

Keywords

Gastric cancer Surgery Chemotherapy 

Abbreviations

PG

Palliative gastrectomy

PC

Palliative chemotherapy

UO

Unresectable operation

NC

No chemotherapy

DFS

Disease-free survival

OS

Overall survival

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Sheng-Zhang Lin
    • 1
  • Hong-Fei Tong
    • 1
  • Tao You
    • 1
  • Yao-Jun Yu
    • 1
  • Wei-Jun Wu
    • 1
  • Cong Chen
    • 1
  • Wei Zhang
    • 1
  • Bing Ye
    • 1
  • Chun-Ming Li
    • 1
  • Zhi-Qiang Zhen
    • 1
  • Jia-Rong Xu
    • 1
  • Jun-Liang Zhou
    • 1
  1. 1.Department of General Surgery, Second Affiliated HospitalWenzhou Medical CollegeWenzhouChina

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